Single high dose atorvastatin does not ameliorate endothelial function and large arterial stiffness in dyslipidemic patients without atherosclerosis

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dc.contributor.authorTulmaç, M.
dc.contributor.authorŞimşek, V.
dc.contributor.authorTireli, E.
dc.contributor.authorŞahin, O.
dc.contributor.authorYildirim, N.
dc.contributor.authorDoğru, M. T.
dc.contributor.authorEbinç, H.
dc.date.accessioned2020-06-25T18:06:34Z
dc.date.available2020-06-25T18:06:34Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Many studies show that statins have beneficial effects on atherosclerotic risk factors and markers such as flow mediated dilatation (FMD). However, studies on early effects of statins on endothelial function of non atherosclerotic humans are limited. Aim: The purpose of this study was to determine whether a single high dose of atorvastatin could improve endothelial function and large arterial stiffness in statin naive dyslipidemic non-atherosclerotic patients. Materials and Methods: Thirty statin naive dyslipidemic non-atherosclerotic patients from Cardiology Outpatient Clinic were enrolled. Arterial stiffness and endothelial function of patients were evaluated by assessing the finger photoplethysmography and the flow-mediated dilatation (FMD) of the brachial artery before and 24 hour after oral administration of 80 mg atorvastatin. Results: Stiffness indices and FMD 24 hours after administration of 80mg atorvastatin did not differ from baseline measurements (6.89 +/- 1.90 vs 7.06 +/- 2.37 p : NS and 9.13 +/- 6.07 vs 9.80 +/- 6.34 p : NS). Conclusions: Although it is widely accepted that statins improve endothelial function, evidences of early effect might largely be associated with endothelial injury. Our study suggests that beneficial early effects of statins might not be applicable to patients without atherosclerosis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage828en_US
dc.identifier.issn1128-3602
dc.identifier.issue6en_US
dc.identifier.pmid22913216
dc.identifier.scopus2-s2.0-84864263765
dc.identifier.scopusqualityQ2
dc.identifier.startpage824en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5254
dc.identifier.volume16en_US
dc.identifier.wosWOS:000305823100016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtorvastatinen_US
dc.subjectFlow-mediated dilatationen_US
dc.subjectStiffness indexen_US
dc.titleSingle high dose atorvastatin does not ameliorate endothelial function and large arterial stiffness in dyslipidemic patients without atherosclerosisen_US
dc.typeArticle

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