Endogenous sex steroids and bone mineral density in healthy men

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dc.contributor.authorKeles, ışık
dc.contributor.authorAydin, Gülümser
dc.contributor.authorBasar, M. Murad
dc.contributor.authorHayran, Mutlu
dc.contributor.authorAtalar, Ebru
dc.contributor.authorOrkun, Sevim
dc.contributor.authorBatislam, Ertan
dc.date.accessioned2020-06-25T17:41:13Z
dc.date.available2020-06-25T17:41:13Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.descriptionBatislam, Ertan/0000-0002-7493-4573
dc.description.abstractObjective. - To evaluate the role of endogenous sex steroids on bone mineral density (BMD) in healthy Turkish men. Methods. - Serum total testosterone (TT), free testosterone (FT), dehydroepiandrosterone sulfate and estradiol levels were assayed in 174 healthy men of 240 volunteers, aged 22-76 years. Dual-energy X-ray absorptiometry was used to measure the BMD (g/cm(2)) of lumbar spine, femoral neck and non-dominant proximal and distal radius-ulna sites. Linear regressions were conducted using each BMD site as the dependent variable and each sex. steroid as the independent variable. Four models were run for each bone site and sex steroid; crude, age-adjusted, adjusted for age and body mass index (BMI), and adjusted for age, BMI and cigarette-smoking. Results. - The mean age and BMI of men enrolled in the study were 47.7 +/- 13.7 years and 26.9 +/- 3.6 kg/m(2). Log of FT was significantly associated with the BMD of distal forearm in all models analyzing the crude and adjusted effects. Dehydroepiandrosterone sulfate effect on BMD of proximal forearm came closer to the level of statistical significance when adjusted with age, BMI and cigarette-smoking. Estradiol and TT levels were not found to be associated with BMD of any sites measured. Conclusion. - Among the endogenous sex steroids in men, predominantly FT seems to be one of the determinants of BMD. Therefore a decrease in serum levels of testosterone in aging male or secondary causes may negatively affect BMD. (c) 2005 Published by Elsevier SAS.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jbspin.2005.04.003
dc.identifier.endpage85en_US
dc.identifier.issn1297-319X
dc.identifier.issue1en_US
dc.identifier.pmid16087380
dc.identifier.scopus2-s2.0-32044475157
dc.identifier.scopusqualityQ2
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org/10.1016/j.jbspin.2005.04.003
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3657
dc.identifier.volume73en_US
dc.identifier.wosWOS:000235408200016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofJoint Bone Spine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbone mineral densityen_US
dc.subjectsex steroidsen_US
dc.subjecthormoneen_US
dc.subjectmenen_US
dc.titleEndogenous sex steroids and bone mineral density in healthy menen_US
dc.typeArticle

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