EFFECTS OF OBESITY ON THE SERUM BMP15, GDF9, AND KISSPEPTIN CONCENTRATIONS IN WOMEN OF REPRODUCTIVE AGE

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dc.contributor.authorArikan, Funda Bulut
dc.contributor.authorSagsoz, Nevin
dc.date.accessioned2025-01-21T16:38:20Z
dc.date.available2025-01-21T16:38:20Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: As BMP15, GDF9, and kisspeptin all play critical roles in folliculogenesis and fertilization, investigating the possible relationship between obesity and these three factors could prove crucial in relation to understanding the role of obesity in infertility. Thus, the present study sought to determine the effects of obesity on the serum BMP15, GDF9, and kisspeptin concentrations in women of reproductive age. Methods: Ninety female participants were equally divided into three groups: class-1 obese (n=30), class-2 obese (n=30), and normal weight (control; n=30). The participants' serum BMP15, GDF9, and AMH concentrations were measured. Moreover, the serum kisspeptin concentrations were evaluated in the class-1 obese and control groups by means of the enzyme-linked immunosorbent assay (ELISA) method while the participants were in their menstrual period. Results: The serum BMP15 and kisspeptin concentrations were found to be much higher in the control group than in both obese groups (p=0.001 and p=0.01, respectively). While the GDF9 concentration exhibited a statistically significant positive correlation with age, the BMP15 concentration exhibited a positive correlation with the kisspeptin and LH concentrations in the control group. In addition, a positive correlation was identified between the BMP15 concentration and both age and the glucose level and a negative correlation with the insulin level in both the obese groups. Conclusions: Obesity appears to reduce the serum BMP15 and kisspeptin concentrations in obese women of repro ductive age. This reduction may represent a milestone in reproductive dysfunction and may be used to predict the success of infertility treatment in obese women.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale University [2019/050]
dc.description.sponsorship& nbsp;& nbsp;This study was supported by the Scientific Research Projects Coordination Unit of Kirikkale University (Project number: 2019/050)
dc.identifier.doi10.5937/jomb0-37329
dc.identifier.endpage400
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue3
dc.identifier.pmid37790202
dc.identifier.scopus2-s2.0-85173165940
dc.identifier.scopusqualityQ3
dc.identifier.startpage392
dc.identifier.urihttps://doi.org/10.5937/jomb0-37329
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24642
dc.identifier.volume42
dc.identifier.wosWOS:001044436200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Medical Biochemists Serbia
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectobesity; BMP15; GDF9; kisspeptin; reproduc-tive
dc.titleEFFECTS OF OBESITY ON THE SERUM BMP15, GDF9, AND KISSPEPTIN CONCENTRATIONS IN WOMEN OF REPRODUCTIVE AGE
dc.typeArticle

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