One-pot facile synthesis of silk sericin-capped gold nanoparticles by UVC radiation: Investigation of stability, biocompatibility, and antibacterial activity

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dc.contributor.authorAkturk, Omer
dc.contributor.authorGok, Zehra Gun
dc.contributor.authorErdemli, Ozge
dc.contributor.authorYigitoglu, Mustafa
dc.date.accessioned2020-06-25T18:30:44Z
dc.date.available2020-06-25T18:30:44Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionErdemli, Ozge/0000-0001-8606-8863; GUN GOK, Zehra/0000-0001-6426-0395
dc.description.abstractHerein, an easy one-pot synthesis method for gold nanoparticles (AuNPs), involving only gold salt and sericin extracted from silkworm cocoon in the presence of ultraviolet C (UVC) radiation, was developed. Nanoparticle formation was confirmed by characteristic surface plasmon resonance peaks at 520-540 nm wavelengths, and the influence of silk sericin on enhancing the colloidal stability of AuNPs was confirmed. Transmission electron microscopy examination showed the average size (<10 nm) and size distribution decreased significantly with higher sericin concentration. No antibacterial activity was observed on Gram-positive Bacillus subtilis or Gram-negative Escherichia coli for sole AuNPs (0.065-0.26 mg/ml), but the conjugation of AuNPs with streptomycin antibiotic decreased significantly the required minimum inhibitory concentration doses, as also confirmed with agar plating, Scanning Electron Microscopy and Atomic Force Microscopy analyses. Furthermore, sericin-capped AuNPs showed high cell viabilities (>100%) and no sign of any detectable apoptosis or necrosis in 1-day incubation. Also, high real-time cell proliferation results of AuNPs competitive with positive control groups implied excellent in vitro biocompatibility. These results evidenced that sericin enhanced the colloidal stability of AuNPs and the biological activities of sericin-capped AuNPs reported here could render them suitable nanoscale vehicles for biomedical applications.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects (BAP) Coordination UnitKirikkale University [2016/141]en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects (BAP) Coordination Unit, Grant/Award Number: 2016/141en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/jbm.a.36771
dc.identifier.endpage2679en_US
dc.identifier.issn1549-3296
dc.identifier.issn1552-4965
dc.identifier.issue12en_US
dc.identifier.pmid31393664
dc.identifier.scopus2-s2.0-85070825112
dc.identifier.scopusqualityQ1
dc.identifier.startpage2667en_US
dc.identifier.urihttps://doi.org/10.1002/jbm.a.36771
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7713
dc.identifier.volume107en_US
dc.identifier.wosWOS:000481781400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biomedical Materials Research Part A
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantibacterial activityen_US
dc.subjectbiocompatibilityen_US
dc.subjectBombyx mori silk sericinen_US
dc.subjectcolloidal stabilityen_US
dc.subjectgold nanoparticlesen_US
dc.titleOne-pot facile synthesis of silk sericin-capped gold nanoparticles by UVC radiation: Investigation of stability, biocompatibility, and antibacterial activityen_US
dc.typeArticle

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