Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson's Disease

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dc.authoridCOMI, CRISTOFORO/0000-0002-6862-9468
dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.authoridDragic, Milorad/0000-0003-4855-6131
dc.authoridMejias-Estevez, Rebeca/0000-0003-1936-7219
dc.authoridFONTAN-LOZANO, ANGELA/0000-0003-1646-0952
dc.authoridSaponjic, Jasna/0000-0002-6903-9056
dc.authoridZeljkovic, Milica/0000-0002-5608-4384
dc.contributor.authorSaponjic, Jasna
dc.contributor.authorMejias, Rebeca
dc.contributor.authorNikolovski, Neda
dc.contributor.authorDragic, Milorad
dc.contributor.authorCanak, Asuman
dc.contributor.authorPapoutsopoulou, Stamatia
dc.contributor.authorGursoy-Ozdemir, Yasemin
dc.date.accessioned2025-01-21T16:40:57Z
dc.date.available2025-01-21T16:40:57Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractParkinson's disease (PD) is a chronic, age-related, progressive multisystem disease associated with neuroinflammation and immune dysfunction. This review discusses the methodological approaches used to study the changes in central and peripheral immunity in PD, the advantages and limitations of the techniques, and their applicability to humans. Although a single animal model cannot replicate all pathological features of the human disease, neuroinflammation is present in most animal models of PD and plays a critical role in understanding the involvement of the immune system (IS) in the pathogenesis of PD. The IS and its interactions with different cell types in the central nervous system (CNS) play an important role in the pathogenesis of PD. Even though culture models do not fully reflect the complexity of disease progression, they are limited in their ability to mimic long-term effects and need validation through in vivo studies. They are an indispensable tool for understanding the interplay between the IS and the pathogenesis of this disease. Understanding the immune-mediated mechanisms may lead to potential therapeutic targets for the treatment of PD. We believe that the development of methodological guidelines for experiments with animal models and PD patients is crucial to ensure the validity and consistency of the results.
dc.description.sponsorshipCOST (European Cooperation in Science and Technology) [CA 21117]
dc.description.sponsorshipThis publication is based upon the work from COST Action IMMUPARKNET (CA 21117) supported by COST (European Cooperation in Science and Technology www.cost.eu).
dc.identifier.doi10.3390/ijms25084330
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue8
dc.identifier.pmid38673915
dc.identifier.scopus2-s2.0-85191376334
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ijms25084330
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24797
dc.identifier.volume25
dc.identifier.wosWOS:001210128700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectParkinson's disease; immune systems; neuroinflammation; neurodegeneration; peripheral immune cells; animal models; cellular models
dc.titleExperimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson's Disease
dc.typeReview Article

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