Synthesis, structural characterization, and cytotoxic activity of new spirocyclic octachlorocyclotetraphosphazenes

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dc.contributor.authorIsiklan, Muhammet
dc.contributor.authorSayin, Levent
dc.contributor.authorSonkaya, Omer
dc.contributor.authorHokelek, Tuncer
dc.contributor.authorTurk, Mustafa
dc.contributor.authorOguztuzun, Serpil
dc.date.accessioned2020-06-25T18:17:13Z
dc.date.available2020-06-25T18:17:13Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionHokelek, Tuncer/0000-0002-8602-4382
dc.description.abstractOctachlorocyclotetraphosphazene, N4P4Cl8, (1) was reacted with N, N-dibenzylethylenediamine to synthesize partially substituted monospiro- (2), dispiro- (5) and tetraspirocyclotetraphosphazene (8) derivatives. The reactions of 2 and 5 with excess pyrrolidine and morpholine produced fully substituted pyrrolidino (3 and 6) and morpholino (4 and 7) spirocyclotetraphosphazenes. The structures of the compounds were determined with 1D (H-1, C-13, P-31, and DEPT) NMR, 2D (HSQC) NMR, ESI-MS, FTIR, and elemental analysis. The solid-state structures of 6 and 7 were examined by X-ray crystallography. In 7, intramolecular C-H...O hydrogen bonds link the molecules into centrosymmetric dimmers. The cytotoxic activity of all the compounds against human cervix carcinoma cell lines (HeLa) was investigated. The study showed that these compounds exert limited cytotoxic, apoptotic and necrotic effects on HeLa cancer cell lines.en_US
dc.description.sponsorshipKirikkale University, Scientific Research Projects Coordination UnitKirikkale University [2005/19]; Hacettepe University, Scientific Research UnitHacettepe University [0202602002]en_US
dc.description.sponsorshipThe authors gratefully acknowledge the "Kirikkale University, Scientific Research Projects Coordination Unit" Grant No. 2005/19 and "Hacettepe University, Scientific Research Unit" Grant No. 0202602002 for financial support.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/10426507.2016.1160240
dc.identifier.endpage1222en_US
dc.identifier.issn1042-6507
dc.identifier.issn1563-5325
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-84976299765
dc.identifier.scopusqualityQ3
dc.identifier.startpage1216en_US
dc.identifier.urihttps://doi.org/10.1080/10426507.2016.1160240
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6718
dc.identifier.volume191en_US
dc.identifier.wosWOS:000382941000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPhosphorus Sulfur And Silicon And The Related Elements
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclotetraphosphazenesen_US
dc.subjectspirophosphazenesen_US
dc.subjectcrystal structureen_US
dc.subjectspectroscopyen_US
dc.subjectHeLa cancer cell lineen_US
dc.subjectcytotoxicityen_US
dc.titleSynthesis, structural characterization, and cytotoxic activity of new spirocyclic octachlorocyclotetraphosphazenesen_US
dc.typeArticle

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