Effects of acute aerobic exercise on cytokines, klotho, irisin, and vascular endothelial growth factor responses in rheumatoid arthritis patients

Basit Öğe Kaydı
dc.authoridDeniz, Gulnihal/0000-0002-5944-8841
dc.contributor.authorErcan, Zubeyde
dc.contributor.authorDeniz, Gulnihal
dc.contributor.authorYentur, Songul Baglan
dc.contributor.authorArikan, Funda Bulut
dc.contributor.authorKaratas, Ahmet
dc.contributor.authorAlkan, Gokhan
dc.contributor.authorKoca, Suleyman Serdar
dc.date.accessioned2025-01-21T16:38:14Z
dc.date.available2025-01-21T16:38:14Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes cartilage and bone damage as well as disability. Aims The aim of this study was to examine the effects of acute aerobic exercise on cytokines such as serum interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), Tumor Necrosis Factor-alpha (TNF-alpha) and irisin, vascular endothelial growth factor(VEGF) and klotho in RA patients. Methods Forty RA patient and 40 healthy volunteers of the same age participated in this study. All participants walked on the treadmill for 30 minutes at 60-80% of maximal heart rate. Blood samples were taken before and immediately after the exercise. Serum levels of IL-6, IL1 beta, TNF-alpha and irisin, VEGF and klotho were measured by enzyme-linked immunosorbent analysis. Results Baseline levels of inflammatory cytokines, irisin, VEGF and klotho were found to be higher in RA patients compared to the control group. In both groups, there was an increase in serum klotho levels after exercise compared to baseline (p<0.05), while a decrease in IL1 beta, TNF-alpha levels were observed. While serum VEGF level decreased in RA group, it increased in the control group(p<0.05). Irisin levels decreased in both groups. IL-6 level did not change in the control group, while it increased in RA group. A single exercise session had an acute anti-inflammatory effect in RA patients. Conclusion It can be concluded that acute aerobic exercise can be beneficial for patients with RA through cytokine, irisin, klotho and VEGF levels, and also it can be safely implemented to the RA rehabilitation program for additional anti-inflammatory effects. Trial registration ClinicalTrials.gov: NCT04439682
dc.description.sponsorshipFirat University Scientific Research Projects Foundation [SYO.20.01]
dc.description.sponsorshipThis study was financially supported by Firat University Scientific Research Projects Foundation with the project number SYO.20.01.
dc.identifier.doi10.1007/s11845-022-02970-7
dc.identifier.endpage497
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue1
dc.identifier.pmid35296975
dc.identifier.scopus2-s2.0-85126344279
dc.identifier.scopusqualityQ1
dc.identifier.startpage491
dc.identifier.urihttps://doi.org/10.1007/s11845-022-02970-7
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24602
dc.identifier.volume192
dc.identifier.wosWOS:000769903800002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer London Ltd
dc.relation.ispartofIrish Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAcute aerobic exercise; Cytokine; Irisin; Klotho; Rheumatoid arthritis; VEGF
dc.titleEffects of acute aerobic exercise on cytokines, klotho, irisin, and vascular endothelial growth factor responses in rheumatoid arthritis patients
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu