Peripheral and central smell regions in children with epilepsy: An MRI evaluation

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dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.contributor.authorAlpcan, Aysegul
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorInal, Mikail
dc.contributor.authorErkmen, SelminPerihan Komurcu
dc.contributor.authorSencan, Ziya
dc.date.accessioned2025-01-21T16:43:22Z
dc.date.available2025-01-21T16:43:22Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: We investigated the peripheral and central olfactory regions in children with epilepsy using cranial MRI. Methods: In this retrospective study, cranial MRI images were obtained from 23 children with epilepsy and 23 healthy controls. Olfactory bulb (OB) volume and olfactory sulcus (OS) depth in the peripheral olfactory region and insular cortex and corpus amygdala areas in the central olfactory region were measured. Results: There was no significant difference in the OB volume and OS depth in the peripheral olfactory regions in the two groups (p > 0.05). In the central olfactory region, the insular cortex and corpus amygdala areas in the epilepsy group were significantly smaller than those in the control group (p < 0.05). In both groups, the OS depth on the right side was significantly higher than that on the left side (p < 0.05). In the epilepsy group, there were positive correlations between each of the OB volumes, OS depths, insular cortex areas, and corpus amygdala areas bilaterally (p < 0.05). In both groups, there were positive correlations between the OB volume and OS depth, OS depth and insular cortex area and insular cortex area and corpus amygdala areas (p < 0.05). Conclusion: A change in the central olfactory region in epileptic patients may be related to central tissue damage due to epilepsy. This finding has important implications for epilepsy patients, with early diagnosis and treatment potentially preventing a reduction in the volumes/depths of components of the central olfactory region in the pediatric population.
dc.identifier.doi10.1016/j.jocn.2021.12.001
dc.identifier.endpage105
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.pmid34929660
dc.identifier.scopus2-s2.0-85120978449
dc.identifier.scopusqualityQ1
dc.identifier.startpage99
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2021.12.001
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25253
dc.identifier.volume95
dc.identifier.wosWOS:000754080600016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofJournal of Clinical Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectEpilepsy; Children; Cranial MRI; Olfactory bulb volume; Olfactory sulcus depth; Insular cortex area; Corpus amygdala area
dc.titlePeripheral and central smell regions in children with epilepsy: An MRI evaluation
dc.typeArticle

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