Clinical performance and biocompatibility of hyaluronan-based heparin-bonded extracorporeal circuits in different risk cohorts

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dc.contributor.authorGunaydin, Serdar
dc.contributor.authorMcCusker, Kevin
dc.contributor.authorSari, Tamer
dc.contributor.authorOnur, Mehmet Ali
dc.contributor.authorZorlutuna, Yaman
dc.date.accessioned2020-06-25T17:51:17Z
dc.date.available2020-06-25T17:51:17Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionONUR, MEHMET/0000-0002-3630-7982
dc.description.abstractThis prospective randomized study compares novel hyaluronan-based heparin-bonded circuits vs. uncoated controls across EuroSCORE patient risk strata including biomaterial evaluation. Over a two-year period, 90 patients undergoing coronary artery bypass grafting were prospectively randomized to one of the two perfusion protocols: Group 1 was treated with hyaluronan-based heparin-bonded preconnected circuits (Vision HFO-GBS (TM), Gish, CA, USA) and Group 2 with identical uncoated controls. Each group was composed of three subgroups (n = 15) with respect to preoperative evaluation of low (EuroSCORE 0-2), medium (3-5) and high (6+) risk patients. Blood samples were collected after induction (T1) and heparinization (T2), 15 min after cardiopulmonary bypass start (T3), before cessation of CPB (T4), 15 min after reversal (T5), and the first postoperative day (T6). In high-risk patients, platelet counts demonstrated significant preservation at T4, T5 and leukocyte counts were lower at T5 in hyaluronan group (P <= 0.05 vs. control). C3a (ng.ml(-1)) levels were significantly lower at T3 (0.2 +/- 0.04 vs. 0.31 +/- 0.05), T4 (0.25 +/- 0.04 vs. 0.51 +/- 0.05), T5 (0.38 +/- 0.04 vs. 0.56 +/- 0.05) and interleukin-6 (pg.ml(-1)) at T4 (91 +/- 18 vs. 124 +/- 20), T5 (110 +/- 20 vs. 220 +/- 25) in coated group vs. control (P <= 0.05). Protein desorption (microalbumin) on fibers (mg.mm(-3)) was less in hyaluronan vs. control groups (P <= 0.05). Hyaluronan coating reduced platelet adhesion and cell adsorption, and modulated inflammatory response in high-risk patients. (c) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.en_US
dc.description.sponsorshipResearch Fund of University of KirikkaleKirikkale University [08/34]en_US
dc.description.sponsorshipThis study was supported by the Research Fund of University of Kirikkale (08/34).en_US
dc.identifier.citationSerdar Gunaydin, Kevin McCusker, Tamer Sari, Mehmet Ali Onur, Yaman Zorlutuna,(2010). Clinical performance and biocompatibility of hyaluronan-based heparin-bonded extracorporeal circuits in different risk cohorts, Interactive CardioVascular and Thoracic Surgery, 10(3), , 371–376.en_US
dc.identifier.doi10.1510/icvts.2009.220756
dc.identifier.endpage376en_US
dc.identifier.issn1569-9293
dc.identifier.issue3en_US
dc.identifier.pmid20026488
dc.identifier.scopus2-s2.0-77649277073
dc.identifier.scopusqualityN/A
dc.identifier.startpage371en_US
dc.identifier.urihttps://doi.org/10.1510/icvts.2009.220756
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4782
dc.identifier.volume10en_US
dc.identifier.wosWOS:000208480700007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofInteractive Cardiovascular And Thoracic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiopulmonary bypassen_US
dc.subjectHyaluronic aciden_US
dc.subjectCoronary artery bypass graftingen_US
dc.titleClinical performance and biocompatibility of hyaluronan-based heparin-bonded extracorporeal circuits in different risk cohortsen_US
dc.typeArticle

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