Etiology of senile osteoporosis - A hypothesis

Basit Öğe Kaydı
dc.contributor.authorAtık, O. Sahap
dc.contributor.authorUslu, M. Murad
dc.contributor.authorEksioglu, Fatih
dc.contributor.authorSatana, Tolgay
dc.date.accessioned2020-06-25T17:41:05Z
dc.date.available2020-06-25T17:41:05Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOsteoporosis is a major health problem characterized by compromised bone strength predisposing patients to an increased risk of fracture. It may cause morbidity and mortality in elderly men and women. The etiologic factors that lead to senile osteoporosis still are unclear. Based on the available experimental and clinical evidence, we update our earlier proposal that zinc deficiency plays a role in the pathogenesis of senile osteoporosis. However, the mechanism of zinc deficiency in osteoporosis remains unclear. Zinc deficiency may lead to the increase of endogenous heparin probably causing degranulation of mast cells and release of endogenous heparin, and an increase in the bone-resorbing effect of prostaglandin E2. Endogenous heparin and prostaglandin E2 are probably cofactors of parathyroid hormone and may have a role in the pathogenesis of senile osteoporosis enhancing the action of parathyroid hormone. Therefore, zinc replacement by dietary zinc supplementation might be valuable to prevent or treat senile osteoporosis. Additional studies are necessary for the evaluation of the possible role of zinc in the etiology of senile osteoporosis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/01.blo.0000200235.76565.c8
dc.identifier.endpage27en_US
dc.identifier.issn0009-921X
dc.identifier.issn1528-1132
dc.identifier.issue443en_US
dc.identifier.pmid16462422
dc.identifier.scopus2-s2.0-33645279044
dc.identifier.scopusqualityQ1
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1097/01.blo.0000200235.76565.c8
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3624
dc.identifier.wosWOS:000243019900010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofClinical Orthopaedics And Related Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEtiology of senile osteoporosis - A hypothesisen_US
dc.typeArticle

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