Periodic monitoring of persistent organic pollutants and molecular damage in Cyprinus carpio from Buyuk Menderes River

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dc.contributor.authorCagdas, Beste
dc.contributor.authorKocagoz, Rasih
dc.contributor.authorOnat, Ilgen
dc.contributor.authorPercin, Fatih
dc.contributor.authorOzaydin, Okan
dc.contributor.authorOrhan, Hilmi
dc.date.accessioned2020-06-25T18:23:12Z
dc.date.available2020-06-25T18:23:12Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.description.abstractConcentrations of persistent organic pollutants (POPs) were quantified in river water and sediment, as well as in the liver and muscle tissues of Cyprinus carpio that were sampled four times in a year at three stations in the Buyuk Menderes River (BMR). Potential biomarkers of possible cellular molecular damage, namely lipid peroxidation (LPO) degradation products, protein carbonyls (PCO) and DNA repair product 8-hydroxy-2' -deoxyguanosine (8-OHdG), were analysed. All the targeted pollutants were measurable both in biotic and abiotic samples. Interestingly, the results suggested that there was recent organochlorine pesticide (OCP) input into the river water in the first two sampling periods in all stations in contrast to prohibition, while input of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) was not detected. Liver POP concentrations were higher than in muscle, as expected, and were found to decrease from the first to the fourth sampling period in all stations, except PBDEs. Levels of LPO degradation products in the liver and in muscle tissues decreased from the first to the fourth sampling period. This suggests that these markers reflect the lipid damage in respective tissues due to the tissue burden of targeted POPs. Protein carbonyls were the highest in the first sampling period, followed by a dramatic decrease in the second, and then a gradual increase towards the fourth sampling period in all stations. 8-OHdG levels were lower in Saraykoy station in the first sampling period. Among the measured biomarkers, only several LPO degradation products were significantly correlated with OCPs and PCBs in liver tissue.en_US
dc.description.sponsorshipThe Scientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [108Y049]; Ege University Faculty of Pharmacy BAP [09ECZ013, 09ECZ017, 11ECZ004]; [09BIL002]en_US
dc.description.sponsorshipThis study was supported by a grant from The Scientific and Technical Research Council of Turkey (TUBITAK) by the grant number 108Y049, and partially by Ebiltem 09BIL002 and by the Ege University Faculty of Pharmacy BAP of 09ECZ013, 09ECZ017 and 11ECZ004. The FABAL facility of Faculty of Pharmacy was utilised in various sample preparation procedures and analyses.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s11356-015-4848-1
dc.identifier.endpage4251en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue5en_US
dc.identifier.pmid26081778
dc.identifier.scopus2-s2.0-84931035496
dc.identifier.scopusqualityQ1
dc.identifier.startpage4241en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-015-4848-1
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7039
dc.identifier.volume24en_US
dc.identifier.wosWOS:000397007200003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science And Pollution Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPOPsen_US
dc.subjectBuyuk Menderes Riveren_US
dc.subjectLipid peroxidation degradation productsen_US
dc.subjectProtein carbonylsen_US
dc.subjectDNA damageen_US
dc.subjectCyprinus carpioen_US
dc.titlePeriodic monitoring of persistent organic pollutants and molecular damage in Cyprinus carpio from Buyuk Menderes Riveren_US
dc.typeArticle

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