The Relationship between Serum Homocysteine Levels and Nonproliferative Diabetic Retinopathy in Type 2 Diabetes Mellitus

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dc.contributor.authorDemirci, Huseyin
dc.contributor.authorOnaran, Zafer
dc.contributor.authorGokcmar, Nesrin
dc.contributor.authorErdamar, Husamettin
dc.contributor.authorOrnek, Nurgul
dc.date.accessioned2020-06-25T18:15:56Z
dc.date.available2020-06-25T18:15:56Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionOrnek, Nurgul/0000-0003-3068-1831
dc.description.abstractObjective: To evaluate the relationship between serum homocysteine levels and the presence of nonproliferative diabetic retinopathy (NPDR) in type 2 Diabetes Mellitus (T2DM) patients Methods: One-hundred patients with a diagnosis of T2DM and 30 healthy control subjects whose age and sex were similar were included in this study. In diabetic patients retinopathy was assessed by ophthalmological examination. Homocysteine, fasting glucose, HbA1C, triglyceride, total cholesterol, high density lipoprotein and low density lipoprotein levels were analyzed in the blood samples in both groups. Also microalbumin levels were analyzed in 24-hour urine samples. T2DM patients were further divided into two groups according to the presence of retinopathy as patients with NPDR (Group 1, n=32) and without retinopathy (Group 2, n=68). Results: There was no statistically significant difference in the homocysteine levels between the T2DM group and the control group (13.13 +/- 4.35 mu mol/l and 12.29 +/- 4.81 mu mol/l, respectively, p>0.05). Although homocysteine levels were higher in the patients with diabetic retinopathy (Group 1) than the diabetic patients without any diabetic complication (Group 2), the difference was not statistically significant (13.21 +/- 4.23mmol/l and 12.96 +/- 4.60mmol/l, respectively, p>0.05). Conclusion: There was no increase in serum homocysteine levels in T2DM when there was no additional diabetic or cardiovascular complication other than NPDR. Our study, by demonstrating that serum homocysteine level was irrelevant to the presence of NPDR, suggests that homocysteine does not play a role at the early stages of retinopathy.en_US
dc.identifier.citationDemirci H., Onaran Z., Gökçınar N. B., Erdamar H., Örnek N. (2015). The Relationship between Serum Homocysteine Levels and Nonproliferative Diabetic Retinopathy in Type 2 Diabetes Mellitus. Gazi Medical Journal, 26(3), 88 - 91.en_US
dc.identifier.doi10.12996/gmj.2015.28
dc.identifier.endpage91en_US
dc.identifier.issn2147-2092
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84936867777
dc.identifier.scopusqualityQ4
dc.identifier.startpage88en_US
dc.identifier.trdizinid212364
dc.identifier.urihttps://doi.org/10.12996/gmj.2015.28
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6351
dc.identifier.volume26en_US
dc.identifier.wosWOS:000217477300004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGazi Univ, Fac Meden_US
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectType 2 diabetes mellitusen_US
dc.subjectnonproliferative diabetic retinopathyen_US
dc.subjectserum homocysteine levelen_US
dc.titleThe Relationship between Serum Homocysteine Levels and Nonproliferative Diabetic Retinopathy in Type 2 Diabetes Mellitusen_US
dc.typeArticle

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