Synthesis and biological activity of ferrocenyl furoyl derivatives
Yükleniyor...
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Due to the fact that ferrocene and furan derivatives have long been known to be one of the most biologically active compounds, preparation of their new derivatives might serve a very important purpose. Herein, five furoyl ferrocenes were synthesized via EAS reaction utilizing AlCl3-EtAlCl2 Lewis acids. The compounds 1-5 were obtained in moderate yields and characterized by IR, H-1-NMR, C-13-NMR, and mass spectrometry. Although toxicity increases with concentration, at 100 mu g/mL concentration, the protection of cell viability was observed to be 70% level. At 50 mg/mL concentration, apoptosis in cancer cells observed was 63 +/- 4% leading to high apoptosis ratio for the compound 3. For the compounds (1-5), the necrotic effects were found to be between 21% and 39% at 50 mu g/mL concentration.
Açıklama
Anahtar Kelimeler
Ferrocene, furan, biological activity, cytotoxicity, synthesis
Kaynak
Inorganic And Nano-Metal Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
47
Sayı
6
Künye
closedAccess
