Synthesis and biological activity of ferrocenyl furoyl derivatives

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dc.contributor.authorTombul, Mustafa
dc.contributor.authorBulut, Adnan
dc.contributor.authorTurk, Mustafa
dc.contributor.authorUcar, Busra
dc.contributor.authorIsilar, Ozer
dc.date.accessioned2020-06-25T18:23:52Z
dc.date.available2020-06-25T18:23:52Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.description.abstractDue to the fact that ferrocene and furan derivatives have long been known to be one of the most biologically active compounds, preparation of their new derivatives might serve a very important purpose. Herein, five furoyl ferrocenes were synthesized via EAS reaction utilizing AlCl3-EtAlCl2 Lewis acids. The compounds 1-5 were obtained in moderate yields and characterized by IR, H-1-NMR, C-13-NMR, and mass spectrometry. Although toxicity increases with concentration, at 100 mu g/mL concentration, the protection of cell viability was observed to be 70% level. At 50 mg/mL concentration, apoptosis in cancer cells observed was 63 +/- 4% leading to high apoptosis ratio for the compound 3. For the compounds (1-5), the necrotic effects were found to be between 21% and 39% at 50 mu g/mL concentration.en_US
dc.description.sponsorshipKirikkale University Scientific Research Centre (Kirikkale BAP)Kirikkale University [2009-39]en_US
dc.description.sponsorshipThe authors gratefully acknowledge the financial support from the Kirikkale University Scientific Research Centre (Kirikkale BAP Grant no: 2009-39).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/15533174.2016.1218510
dc.identifier.endpage869en_US
dc.identifier.issn2470-1556
dc.identifier.issn2470-1564
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85026832966
dc.identifier.scopusqualityQ2
dc.identifier.startpage865en_US
dc.identifier.urihttps://doi.org/10.1080/15533174.2016.1218510
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7208
dc.identifier.volume47en_US
dc.identifier.wosWOS:000396521300012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofInorganic And Nano-Metal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFerroceneen_US
dc.subjectfuranen_US
dc.subjectbiological activityen_US
dc.subjectcytotoxicityen_US
dc.subjectsynthesisen_US
dc.titleSynthesis and biological activity of ferrocenyl furoyl derivativesen_US
dc.typeArticle

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