Effects of medium cut-off dialysis membranes on inflammation and oxidative stress in patients on maintenance hemodialysis

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dc.contributor.authorYeter, Hasan Haci
dc.contributor.authorKorucu, Berfu
dc.contributor.authorAkcay, Ömer Faruk
dc.contributor.authorDerici, Kürşat
dc.contributor.authorDerici, Ülver
dc.contributor.authorArinsoy, Turgay
dc.date.accessioned2021-01-14T18:10:30Z
dc.date.available2021-01-14T18:10:30Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionYETER, hasan h/0000-0002-5787-1048
dc.description.abstractPurpose Medium cut-off membranes were developed for providing increased clearance of larger middle-molecule uremic toxins. We compared the effect of low-flux, medium cut-off, and high-flux membranes on chronic inflammation and oxidative stress in patients with maintenance hemodialysis. Methods A total of 42 patients were enrolled in this study. Total antioxidant status, total oxidant status, paraoxonase-1, ischemia-modified albumin, total Thiol, disulfide bond, and native Thiol were measured to determine oxidative stress. C-reactive protein was measured to define inflammation. Results 37% of the total patients were females, and the mean age was 52.9 +/- 16 years. Serum albumin and Kt/V were similar between groups during the study period. We did not find any significant difference at baseline in the 3rd and 6th months of the study when we compared the inflammatory marker and oxidative indicator levels between three hemodialysis membranes in the whole study group. In the subgroup analysis of 19 patients with a high C-reactive protein level, we found that the medium cut-off membrane significantly reduced serum C-reactive protein level, when compared to low-flux and high-flux membrane [2.8 mg/L vs. 13.7 mg/L and 6.1 mg/L, respectively,p = 0.05]. However, we did not find a significant change in oxidative stress indicators in patients with high C-reactive protein levels between the three dialysers. Conclusion The medium cut-off membrane has favorable effects on inflammation in patients with maintenance hemodialysis. However, this positive effect could not be demonstrated in oxidative stress.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s11255-020-02562-3
dc.identifier.endpage1789en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue9en_US
dc.identifier.pmid32661626
dc.identifier.scopus2-s2.0-85087797784
dc.identifier.scopusqualityQ2
dc.identifier.startpage1779en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-020-02562-3
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12637
dc.identifier.volume52en_US
dc.identifier.wosWOS:000548170700003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSPRINGERen_US
dc.relation.ispartofINTERNATIONAL UROLOGY AND NEPHROLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExpanded hemodialysisen_US
dc.subjectHemodialysisen_US
dc.subjectInflammationen_US
dc.subjectMedium cut-off dialyseren_US
dc.subjectOxidative stressen_US
dc.titleEffects of medium cut-off dialysis membranes on inflammation and oxidative stress in patients on maintenance hemodialysisen_US
dc.typeArticle

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