The effects of repeated sevoflurane anesthesia on renal tubular enzymes in rabbits

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dc.contributor.authorBaşar H.
dc.contributor.authorBüyükkoçak Ü.
dc.contributor.authorKaymak Ç.
dc.contributor.authorÖzcan Ş.
dc.contributor.authorTüzüner F.
dc.date.accessioned2020-06-25T15:13:17Z
dc.date.available2020-06-25T15:13:17Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractSevoflurane, one of new inhalation agents, is metabolized to organic and inorganic fluoride metabolites. Nephrotoxicity is due to free fluoride. In this study; we investigated the renal effects of repeated and different concentrations of sevoflurane anesthesia, experimentally. Sensitive urinary indicators n-asetil-d- glukozaminidaz (NAG), alkalen phosfatase (ALP), and gamma glutamil transferase (GGT) were assessed. This study was performed in 14, male New Zelland rabbits. Rabbits were divided into two groups (n=7). Group I (n=7) received sevoflurane 1% and Group II (n=7) 3% sevoflurane with O2+N2O (4 Lmin-1) 3 hours a dayfor 3 days Urine samples were collected via a special apparatus for 24 hours preoperative and after anesthesia. Urine samples were taken five days after the last administration of anesthesia and NAG, ALP and GGT levels in urine were determined. Blood samples taken from ear veins were obtained to determine BUN and Creatine. In Group II, urinary NAG levels increased significantly on the third day and a significant increase in GGT was observed on second and third days. There was no significant change in BUN, Cre and urinary ALP. NAG and GGT levels returned to normal on the 9th day. We concluded that, the effects of repeated sevoflurane administration on renal system are temporary.en_US
dc.identifier.citationBaşar, H., Büyükkoçak, Ü., Kaymak, Ç., Özcan, Ş., Tüzüner, F. (2003). Tavşanlarda tekrarlanan sevofluran uygulamalarının renal tübüler enzimler üzerine etkileri. Anestezi Dergisi, 11(4), 290 - 293.en_US
dc.identifier.endpage293en_US
dc.identifier.issn13000578
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-0346783334
dc.identifier.scopusqualityQ4
dc.identifier.startpage290en_US
dc.identifier.trdizinid20285
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1708
dc.identifier.volume11en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.relation.ispartofAnestezi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNAGAen_US
dc.subjectRenal toxicityen_US
dc.subjectSevofluraneen_US
dc.titleThe effects of repeated sevoflurane anesthesia on renal tubular enzymes in rabbitsen_US
dc.title.alternativeTavşanlarda tekrarlanan sevofluran uygulamalarinin renal tübüler enzimler üzerine etkile?ien_US
dc.typeArticle

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