PREDICTIVE DIAGNOSTIC AND/OR PROGNOSTIC BIOMARKERS OBTAINED FROM ROUTINE BLOOD BIOCHEMISTRY IN PATIENTS WITH SOLITARY INTRACRANIAL TUMOR

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dc.authoridBAKAR, BULENT/0000-0002-6236-7647
dc.contributor.authorYuksel, Ulas
dc.contributor.authorOgden, Mustafa
dc.contributor.authorOzdemir, Alemiddin
dc.contributor.authorKisa, Ucler
dc.contributor.authorBakar, Bulent
dc.date.accessioned2025-01-21T16:43:34Z
dc.date.available2025-01-21T16:43:34Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Radiological and/or laboratory tests may be sometimes inadequate distinguishing glioblastoma from metastatic brain tumors. The aim of this study was to find possible predictive biomarkers produced from routine blood biochemistry analysis results evaluated preoperatively in each patient with solitary brain tumor in distinguishing glioblastoma from metastatic brain tumors as well as revealing shortterm prognosis. Methods: Patients admitted to neurosurgery clinic between January 2015 and September 2018 were included in this study and they were divided into GLIOMA (n=12) and METASTASIS (n=17) groups. Patients' data consisted of age, gender, Glasgow Coma Scale scores, duration of stay in hospital, Glasgow Outcome Scale (GOS) scores and histopathological examination reports, hemoglobin level, leukocyte, neutrophil, lymphocyte, monocyte, eosinophil, basophil and platelet count results, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio values, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels were evaluated preoperatively. Results: The CRP levels of METASTASIS group (143.10 mg/L) were higher than those of GLIOMA group (23.90 mg/L); and it was 82% sensitive and 75% specific in distinguishing metastatic brain tumor from glioblastoma if CRP value was >55.00 mg/L. A positive correlation was determined between GOS score and hemoglobin level and between ESR and CRP values. However, GOS scores were negatively correlated with the ESR level and duration of stay in hospital. Conclusions: Study results demonstrated that CRP values could be predictive biomarker in distinguishing metastatic brain tumor from glioblastoma. In addition, ESR, CRP hemoglobin levels and duration of stay in hospital could be prognostic biomarkers in predicting short-term prognosis of patients with solitary brain tumor.
dc.identifier.doi10.5937/jomb0-24722
dc.identifier.endpage73
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue1
dc.identifier.pmid33584142
dc.identifier.startpage67
dc.identifier.urihttps://doi.org/10.5937/jomb0-24722
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25295
dc.identifier.volume40
dc.identifier.wosWOS:000612357000009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Medical Biochemists Serbia
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectbrain metastasis; C-reactive protein; erythrocyte sedimentation rate; glioma; intracranial tumor; prognosis
dc.titlePREDICTIVE DIAGNOSTIC AND/OR PROGNOSTIC BIOMARKERS OBTAINED FROM ROUTINE BLOOD BIOCHEMISTRY IN PATIENTS WITH SOLITARY INTRACRANIAL TUMOR
dc.typeArticle

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