Retinal Nerve Fiber Layer and Peripapillary Choroidal Thicknesses in Non-Glaucomatous Unilateral Optic Atrophy Compared with Unilateral Advanced Pseudoexfoliative Glaucoma

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dc.contributor.authorKucukevcilioglu, Murat
dc.contributor.authorAyyildiz, Onder
dc.contributor.authorAykas, Seckin
dc.contributor.authorGokce, Gokcen
dc.contributor.authorKoylu, Mehmet Talay
dc.contributor.authorOzgonul, Cem
dc.contributor.authorYumusak, Erhan
dc.date.accessioned2020-06-25T18:23:43Z
dc.date.available2020-06-25T18:23:43Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose: To investigate retinal nerve fiber layer thickness (RNFL-T) and peripapillary choroidal thickness (PC-T) in non-glaucomatous optic atrophy (OA) patients in comparison with unaffected and control eyes, furthermore, to compare thickness profiles with unilateral pseudoexfoliative advanced glaucoma.Materials and Methods: Thirty-three eyes with OA (Group A), 33 unaffected fellow eyes (Group B), 25 right eyes of 25 control subjects (Group C), and 15 eyes with advanced glaucoma (Group D) were enrolled. RNFL-T was measured in six regions by spectral-domain optical coherence tomography. Enhanced depth imaging optical coherence tomography was obtained to evaluate PC-T in corresponding regions.Results: RNFL-T was significantly lower in Group A than in Groups B and C globally and at all peripapillary regions (all p < 0.001). P-CT in Group A was significantly lower globally (p = 0.03) and in three regions (temporal, p = 0.001; temporal-superior, p = 0.01; and nasal-inferior, p = 0.037) versus Group C. However, it was significantly thinner than in Group B in all regions (temporal, p = 0.02; temporal-superior, p = 0.013; nasal-superior, p = 0.044; nasal, p = 0.02; nasal-inferior, p < 0.001; and temporal-inferior, p < 0.001) and globally (p < 0.001). In Group A RNFL-T (thicker superiorly and inferiorly; thinner temporally and nasally) and PC-T (superior > temporal > nasal > inferior) profiles were almost identical to that in unaffected fellow eyes and control eyes. However, Group D showed different patterns with less regional differences in RNFL-T, and the greatest value of PC-T in nasal quadrant.Conclusions: Besides retinal nerve fiber layer thinning, non-glaucomatous OA is associated with choroidal thinning. The RNFL-T and PC-T profiles in advanced glaucoma eyes differed from the common patterns seen among OA eyes, unaffected fellow eyes, and control eyes.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3109/02713683.2016.1170856
dc.identifier.endpage306en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue2en_US
dc.identifier.pmid27348514
dc.identifier.scopus2-s2.0-84976286740
dc.identifier.scopusqualityQ1
dc.identifier.startpage302en_US
dc.identifier.urihttps://doi.org/10.3109/02713683.2016.1170856
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7173
dc.identifier.volume42en_US
dc.identifier.wosWOS:000395186800020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdvanced glaucomaen_US
dc.subjectoptic atrophyen_US
dc.subjectperipapillary choroiden_US
dc.subjectretinal nerve fiber layeren_US
dc.subjectthickness profileen_US
dc.titleRetinal Nerve Fiber Layer and Peripapillary Choroidal Thicknesses in Non-Glaucomatous Unilateral Optic Atrophy Compared with Unilateral Advanced Pseudoexfoliative Glaucomaen_US
dc.typeArticle

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