Coexistence of different tissue tumourigenesis in an N-methyl-N-nitrosourea-induced mammary carcinoma model: a histopathological report in Sprague-Dawley rats

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dc.contributor.authorEsendağlı, Güneş
dc.contributor.authorYılmaz, G.
dc.contributor.authorCanpınar, Hande
dc.contributor.authorGünel-Özcan, Ayşen
dc.contributor.authorGüç, M. Oğuz
dc.contributor.authorGüç, Dicle
dc.date.accessioned2020-06-25T17:48:57Z
dc.date.available2020-06-25T17:48:57Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionEsendagli, Gunes/0000-0003-4865-2377;
dc.description.abstractN-methyl-N-nitrosourea (MNU), a highly potent carginogen, is widely used to generate mammary tumours in murine species. In a model of MNU-induced mammary carcinogenesis using immature female Sprague-Dawley rats, large mammary tumours (largest dimension >= 0.5 cm) were obtained within a very short period of time. In addition, in the rats bearing MNU-induced mammary carcinomas, there were a number of tumours whose origins were not from mammary tissue but from several different tissues and from mammary non-epithelial tissue. The tumours were of mesenchymal or epithelial origin and they were located in the inguinal region. These tumours were diagnosed as fibroadenoma, combined tubular adenoma and fibroadenoma, hyperkeratotic papilloma, keratinous cyst and malignant peripheral nerve sheath tumour (MPNST) with smooth muscle differentiation. The occurrence of these other tumours in addition to the development of the mammary carcinomas may be attributed to a direct local effect of the intraperitoneal administration of MNU during the sexual development of the immature rats. In the MNU-induced mammary tumour model, coexistence of tumourigenesis in various non-mammary tissues should be considered an important factor that may interfere with experimental procedures and results and also the quality of life of the tumour-bearing animals.en_US
dc.description.sponsorshipEczacibasi Scientific Research and Award Fund; Hacettepe University Scientific Research UnitHacettepe University [05DO3104001]en_US
dc.description.sponsorshipThis study was supported by grants from the Eczacibasi Scientific Research and Award Fund and the Hacettepe University Scientific Research Unit (project no. 05DO3104001). We Wish to thank Dr Sibel Percinel for her helpful supervision in the histopathological evaluations.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1258/la.2008.007076
dc.identifier.endpage64en_US
dc.identifier.issn0023-6772
dc.identifier.issue1en_US
dc.identifier.pmid18987061
dc.identifier.scopus2-s2.0-58349090250
dc.identifier.scopusqualityQ1
dc.identifier.startpage60en_US
dc.identifier.urihttps://doi.org/10.1258/la.2008.007076
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4599
dc.identifier.volume43en_US
dc.identifier.wosWOS:000262991000009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRoyal Soc Medicine Press Ltden_US
dc.relation.ispartofLaboratory Animals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-methyl-N-nitrosoureaen_US
dc.subjectchemical carcinogenesisen_US
dc.subjectmammary carcinomaen_US
dc.subjectanimal modelen_US
dc.titleCoexistence of different tissue tumourigenesis in an N-methyl-N-nitrosourea-induced mammary carcinoma model: a histopathological report in Sprague-Dawley ratsen_US
dc.typeArticle

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