Effects of dexmedetomidine and thymoquinone on erythrocyte deformability in lower limb ischemia reperfusion injury in streptozotocin-induced diabetic rats

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dc.contributor.authorOzer, A.
dc.contributor.authorComu, F. M.
dc.contributor.authorKucuk, A.
dc.contributor.authorKilic, Y.
dc.contributor.authorAlkan, M.
dc.contributor.authorOktar, L.
dc.contributor.authorOzturk, L.
dc.date.accessioned2020-06-25T18:29:50Z
dc.date.available2020-06-25T18:29:50Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractOBJECTIVE: In this study we aimed to evaluate the effect of dexmedetomidine and thymoquinone on erythrocyte deformability in lower limb ischaemia-reperfusion (IR) injury in streptozotocin-induced diabetic rats. MATERIAL AND METHODS: Thirty Wistar albino rats were equally divided into 5 groups (n = 6); randomized control group (Group C), diabetes control group (Group DC), DIR group (Group DIR), DIR group with thymoquinone 25 mg.kg(-1) intraperitoneally (Group DIRT) and Group DIR with dexmedetomidine 100 mu g.kg(-1) intraperitoneally (Group DIRD). Erythrocyte packs were prepared from heparinized blood samples and deformability measurements were performed. RESULTS: IR significantly increased the relative resistance, a marker of erythrocyte deformability when compared to control group (p < 0.05). There were significant differences among the groups in comparisons with ANOVA test (p < 0.0001). Comparisons of the groups DIRD and DIRT revealed similar results (p = 0.824). The values of Group DIR were significantly higher than those of the control, DC, DIRD and DIRT groups (p < 0.0001, p = 0.001, p = 0.004, p = 0.002, respectively). The values of the DC, DIR, DIRD and DIRT groups were significantly higher than those of the control group (p < 0.0001, all). CONCLUSION: Erythrocyte deformability may cause more problems in microcirculation. Dexmedetomidine and thymoquinone may be useful in reducing the adverse effects of this type of injury.en_US
dc.identifier.citationOzer, A., Comu, F. M., Kucuk, A., Kilic, Y., Alkan, M., Oktar, L., Arslan, M., & Ozturk, L. (2018). Effects of dexmedetomidine and thymoquinone on erythrocyte deformability in lower limb ischemia reperfusion injury in streptozotocin-induced diabetic rats. Bratislavske lekarske listy, 119(10), 642–645.en_US
dc.identifier.doi10.4149/BLL_2018_115
dc.identifier.endpage645en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue10en_US
dc.identifier.pmid30345772
dc.identifier.scopus2-s2.0-85055075320
dc.identifier.scopusqualityQ2
dc.identifier.startpage642en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2018_115
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7479
dc.identifier.volume119en_US
dc.identifier.wosWOS:000451638900006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectlower limb ischemia reperfusion injuryen_US
dc.subjectdexmedetomidineen_US
dc.subjectthymoquinoneen_US
dc.subjectdiabetesen_US
dc.subjectraten_US
dc.titleEffects of dexmedetomidine and thymoquinone on erythrocyte deformability in lower limb ischemia reperfusion injury in streptozotocin-induced diabetic ratsen_US
dc.typeArticle

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