Optical Coherence Tomography and Visual Field Findings in Patients With Friedreich Ataxia

Basit Öğe Kaydı
dc.contributor.authorDag, Ersel
dc.contributor.authorOrnek, Nurgul
dc.contributor.authorOrnek, Kemal
dc.contributor.authorErbahceci-Timur, Inci Elif
dc.date.accessioned2020-06-25T18:12:12Z
dc.date.available2020-06-25T18:12:12Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionOrnek, Nurgul/0000-0003-3068-1831
dc.description.abstractBackground: To investigate the optical coherence tomography (OCT) and visual field findings in Friedreich ataxia (FRDA). Methods: Ten eyes of 10 patients with genetically confirmed FRDA were included in this study. Twenty-two eyes of 22 age- and sex-matched volunteers served as controls. All eyes were examined with spectral domain OCT (Retinascan Advanced RS-3000; NIDEK) and Humphrey Field Analyzer (HFA II 750; Zeiss-Humphrey Systems). Results: OCT measurements of the average peripapillary retinal nerve fiber layer (RNFL) thickness, average peripapillary retinal thickness (RT), and foveal RT showed a statistically significant reduction in patients with FRDA (P, 0.0001). There was no statistically significant difference in choroidal thickness. OCT measurements of horizontal cup-to-disc (C/D) ratio, vertical C/D ratio, and average cup area were significantly increased in patients with FRDA. Visual acuity was significantly correlated with age at onset (P = 0.021) and average RNFL value (P = 0.045). There was a significant correlation between foveal thickness and disease duration (P = 0.014). Mean RNFL thickness was significantly correlated with the severity of neurological involvement (P = 0.039). Visual field testing (VFT) revealed a generalized reduction of sensitivity in the patients. Conclusion: Patients with FRDA may have a measurable degree of retinal thinning as determined by OCT and a generalized reduction of sensitivity in VFT. Combining structural and functional findings may be used in the follow-up of patients with FRDA. (C) 2013 by North American Neuro-Ophthalmology Societyen_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/WNO.0000000000000068
dc.identifier.endpage121en_US
dc.identifier.issn1070-8022
dc.identifier.issn1536-5166
dc.identifier.issue2en_US
dc.identifier.pmid24275983
dc.identifier.scopus2-s2.0-84900801645
dc.identifier.scopusqualityQ2
dc.identifier.startpage118en_US
dc.identifier.urihttps://doi.org/10.1097/WNO.0000000000000068
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5803
dc.identifier.volume34en_US
dc.identifier.wosWOS:000337246200003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Neuro-Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleOptical Coherence Tomography and Visual Field Findings in Patients With Friedreich Ataxiaen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Optical Coherence Tomography and Visual Field Findings in Patients With Friedreich Ataxia.pdf
Boyut:
98.65 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu