Effect of Initial Periodontal Treatment on Cardiovascular Risk Markers in Patients with Severe Chronic Periodontitis

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dc.contributor.authorHendek, Meltem Karsiyaka
dc.contributor.authorOlgun, Ebru
dc.contributor.authorKisa, Ucler
dc.date.accessioned2020-06-25T18:30:45Z
dc.date.available2020-06-25T18:30:45Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: The aim of the study was to determine the influence of initial periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases. Materials and Methods: A total of 80 non-smokers with systemically healthy, including 40 patients (29 female, 11 male) with severe chronic periodontitis (test group) and 40 periodontally healthy participants (21 female, 19 male) (control group) were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay. Results: At baseline, all clinical periodontal parameters were significantly higher in the chronic periodontitis group than in the periodontally healthy group (p<0.05). After the initial periodontal treatment, in the test group, all of the clinical periodontal parameters showed a significant decrease compared to the baseline values (p<0.05). At baseline, ADMA, Hcy and MCP-1 levels were significantly higher in the test group than in the control group (p<0.05), and after treatment ADMA and MCP-1 levels showed a significant decrease whereas eNOS level showed significant increase (p<0.05). Conclusion: It was observed that initial periodontal treatment in patients with severe chronic periodontitis has positive effects on cardiovascular risk markers.en_US
dc.description.sponsorshipScientific Research Project Fund of Kirikkale UniversityKirikkale University [2015/029]en_US
dc.description.sponsorshipThe Scientific Research Project Fund of Kirikkale University (project number: 2015/029) supported this research.en_US
dc.identifier.citationHendek, M. K., Olgun, E., & Kisa, U. (2019). Effect of Initial Periodontal Treatment on Cardiovascular Risk Markers in Patients with Severe Chronic Periodontitis. Meandros Medical and Dental Journal, 20(2), 114-120.en_US
dc.identifier.doi10.4274/meandros.galenos.2018.58661
dc.identifier.endpage120en_US
dc.identifier.issn2149-9063
dc.identifier.issue2en_US
dc.identifier.startpage114en_US
dc.identifier.trdizinid363302
dc.identifier.urihttps://doi.org/10.4274/meandros.galenos.2018.58661
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7717
dc.identifier.volume20en_US
dc.identifier.wosWOS:000511859200003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofMeandros Medical And Dental Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectinitial periodontal treatmenten_US
dc.subjectasymmetric dimethylarginineen_US
dc.subjectendothelial nitric oxide synthaseen_US
dc.subjecthomocysteineen_US
dc.subjectmonocyte chemoattractant protein-1en_US
dc.titleEffect of Initial Periodontal Treatment on Cardiovascular Risk Markers in Patients with Severe Chronic Periodontitisen_US
dc.typeArticle

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