The Role of CD68 (+) Histiocytic Macrophages in Nasal Polyp Development

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dc.contributor.authorBayar Muluk, Nuray
dc.contributor.authorArikan, Osman Kursat
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorKilic, Rahmi
dc.contributor.authorTuna Yalcinozan, Eda
dc.date.accessioned2021-01-14T18:10:22Z
dc.date.available2021-01-14T18:10:22Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractObjectives The aim of this study was to investigate the role of CD68 (+) histiocytic macrophages (H-M) in the nasal polyp pathogenesis. Materials and Methods The study group consisted of 24 adult patients with nasal polyposis. The control group consisted of 11 adult patients without nasal polyps. A total of 36 nasal polyp samples (10-nasal cavity, 10-maxillary sinus, and 16-ethmoid sinus) from the study group and 11 inferior turbinate samples from the control group were analyzed by immunohistochemical staining, with monoclonal antibodies against CD68 (+) H-M. Results CD68 positivity was significantly higher than the control group in the subepithelial (SE) layer of the ethmoid sinus, and deep layers of nasal cavity, maxillary, and ethmoid sinuses. In SE and deep layers of ethmoid and maxillary sinuses, CD68 positivity was significantly higher than that of the epithelial layer. In the deep layer, histiocytic macrophages tended to gather around eosinophils. Conclusion The high numbers of CD68 (+) histiocytic macrophages mainly located in deep layer of lamina propria may be responsible for the phagocytosis of eosinophils within the polyp tissue. Therefore, it may be concluded that increased macrophages in nasal polyps do not trigger the growth of nasal polyps. Instead, they may serve to reduce the number of eosinophils in already-developed nasal polyps.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Coordination Unit FundsKirikkale University [2009/16]en_US
dc.description.sponsorshipThis study was supported by "Kirikkale University Scientific Research Projects Coordination Unit Funds" (date: 2009, number: 2009/16).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1055/s-0040-1715593
dc.identifier.issn2193-6331
dc.identifier.issn2193-634X
dc.identifier.pmid34745840
dc.identifier.scopus2-s2.0-85092737502
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1055/s-0040-1715593
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12551
dc.identifier.wosWOS:000575131100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTHIEME MEDICAL PUBL INCen_US
dc.relation.ispartofJOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD68 (+)en_US
dc.subjecthistiocytic macrophagesen_US
dc.subjectpolypen_US
dc.subjectethmoid sinusen_US
dc.subjectmaxillary sinusen_US
dc.subjectnasal cavityen_US
dc.subjectpathogenesisen_US
dc.titleThe Role of CD68 (+) Histiocytic Macrophages in Nasal Polyp Developmenten_US
dc.typeArticle

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