Investigation of the prophylactic and therapeutic effectiveness of oral thyme extract in rats experimentally infected with cryptosporidium parvum

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dc.authoridSevin, Sedat/0000-0003-0475-9092
dc.authoridKaya, Ufuk/0000-0002-4805-0993
dc.authoridSENEL, YASIN/0000-0003-0272-2712
dc.authoridDURU, OZKAN/0000-0002-8792-442X
dc.authoridKARA, Erdal/0000-0001-7047-9502
dc.authoridYasa Duru, Sibel/0000-0002-6803-6339
dc.contributor.authorKara, Erdal
dc.contributor.authorDuru, Sibel Yasa
dc.contributor.authorGokpinar, Sami
dc.contributor.authorDuru, Ozkan
dc.contributor.authorSevin, Sedat
dc.contributor.authorSenel, Yasin
dc.contributor.authorKaya, Ufuk
dc.date.accessioned2025-01-21T16:42:13Z
dc.date.available2025-01-21T16:42:13Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, the prophylactic and therapeutic activities of thyme extract at different concentrations against experimental Cryptosporidium parvum infection in immunosuppressed rats were investigated. Thyme extract was prepared at four different concentrations (10%, 30%, 50%, and 100%) and administered as a single oral dose of 1 mL for evaluation of its prophylactic efficacy. Five consecutive days after infection was detected in all rats, therapeutic evaluations were also performed. According to the results obtained by daily counting of oocysts in stools, the prophylactic and therapeutic effects of thyme extract administration were significant in comparison to the control group (P<0.01). Oocyst shedding continued in the control group at high numbers from the beginning to the end of the study, while oocyst counts in the prophylaxis groups remained low throughout the study. On the other hand, oocyst excretion rates were high in the therapeutic groups and decreased rapidly after thyme extract administration. At the end of the study, oocyst excretion had completely stopped for some rats administered thyme extract. There was no group in which oocyst shedding ceased for all rats. No significant differences were observed in the therapeutic or prophylaxis groups regarding the doses administered (P > 0.01). Renal and hepatic functions were monitored by measuring urea, creatinine, alanine transaminase, and aspartate transaminase levels before and after thyme extract administration. As a result, it was concluded that oral thyme extract administration at the doses applied in this study is effective and safe in the prophylactic and therapeutic treatment of experimental cryptosporidiosis in rats.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale University [2020/039]
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Kirikkale University (Project number 2020/039).
dc.identifier.doi10.1007/s11259-022-10025-6
dc.identifier.endpage673
dc.identifier.issn0165-7380
dc.identifier.issn1573-7446
dc.identifier.issue2
dc.identifier.pmid36323839
dc.identifier.scopus2-s2.0-85141193713
dc.identifier.scopusqualityQ2
dc.identifier.startpage663
dc.identifier.urihttps://doi.org/10.1007/s11259-022-10025-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25018
dc.identifier.volume47
dc.identifier.wosWOS:000877986700002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofVeterinary Research Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectCryptosporidium parvum; Dose; Extract; Prophylaxis; Rat; Thyme; Treatment
dc.titleInvestigation of the prophylactic and therapeutic effectiveness of oral thyme extract in rats experimentally infected with cryptosporidium parvum
dc.typeArticle

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