Radiation Enhancement with Polyethyleneimine-Coated Gold Nanoparticles Under MV Photons

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dc.contributor.authorAytac Arslan, Suheyla
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2020-06-25T18:34:32Z
dc.date.available2020-06-25T18:34:32Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE Radiotherapy is an essential part of cancer management, and about two-thirds of the patients with cancer receive radiation therapy during their treatment. The healthy structures around the tumor are dose limiting in terms of acute and late toxicity. Radiosensitizers (RSs) can be used to enhance intratumoral dose, thus improving the therapeutic ratio. We aimed to investigate the cytotoxicity on normal and cancer cell lines induced by interaction between MV photon irradiation and polyethyleneimine (PEI)-coated gold nanoparticles (AuNPs). METHODS The effects of different concentrations of AuNPs (0.75 mu g/ml, 0.5 mu g/ml, 0.25 mu g/ml, and only medium) and 2-Gy ionizing radiation (IR) were investigated on the L929 fibroblast, DLD-1 colon, and H1299 lung cancer cell lines. Cytoplasmic and nuclear membranes treated with hematoxylin and eosin and double staining were evaluated with light and fluorescence microscopy. Cytotoxicity was determined with the WST-1 method. RESULTS All particles were spherical in shape with 60.98 nm in size. Cell surviving ratios without AuNPs were 96.34% in L929, 89.68% in DLD-1, and 76.93% in H1299 for a single 2-Gy radiation. These ratios were 94.2%, 62.58%, and 40.52% for L929 cells; 72.70%, 41.15%, and 26.71% for DLD-1 cells; and 34.72%, 28.27%, and 17.84% for H1299 cells at concentrations of 0.25 mu g/ml, 0.5 mu g/ml, and 0.75 mu g/ml AuNPs, respectively. CONCLUSION At increased concentrations, isolated unwanted cytotoxic effects of AuNPs could be observed. Radiosen-sitizing effect of PEI-coated AuNPs depends on cell type and AuNP concentration.en_US
dc.identifier.citationArslan S. A., Türk M. (2019). Radiation Enhancement with Polyethyleneimine-Coated Gold Nanoparticles Under MV Photons. Türk Onkoloji Dergisi, 34(2), 100 - 107.en_US
dc.identifier.doi10.5505/tjo.2019.911
dc.identifier.endpage107en_US
dc.identifier.issn1300-7467
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85068540155
dc.identifier.scopusqualityQ4
dc.identifier.startpage100en_US
dc.identifier.trdizinid335207
dc.identifier.urihttps://doi.org/10.5505/tjo.2019.911
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7950
dc.identifier.volume34en_US
dc.identifier.wosWOS:000469789600007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal Of Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGold nanoparticleen_US
dc.subjectmegavoltageen_US
dc.subjectpolyethyleneiinineen_US
dc.subjectradiosensitizationen_US
dc.titleRadiation Enhancement with Polyethyleneimine-Coated Gold Nanoparticles Under MV Photonsen_US
dc.typeArticle

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