Serum vascular endothelial growth factor receptor-2 and adropin levels in age-related macular degeneration

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dc.contributor.authorÖrnek, Nurgul
dc.contributor.authorÖrnek, Kemal
dc.contributor.authorAydin, Süleyman
dc.contributor.authorYılmaz, Musa
dc.contributor.authorÖlmez, Yaşar
dc.date.accessioned2020-06-25T18:16:40Z
dc.date.available2020-06-25T18:16:40Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionOrnek, Nurgul/0000-0003-3068-1831
dc.description.abstractAIM: To investigate the serum levels of vascular endothelial growth factor receptor-2 (VEGFR-2) and adropin in age-related macular degeneration (AMD) patients. METHODS: Ninety-eight AMD patients were included in the study. Seventy-eight age - and sex-matched healthy volunteers were recruited as the control group. Fundus florescein angiography and optical coherence tomography were performed to assess the posterior segment details. Serum VEGFR-2 and adropin levels were measured using enzyme-linked immunosorbent assays and compared between the study groups. RESULTS: AMD group had significantly increased fovea! retinal thickness, serum LDL and HDL levels and significantly decreased subfoveal choroidal thickness (P = 0.01, 0.047, 0.025 and <0.001, respectively). Serum VEGFR-2 level revealed a significant decrease in AMD patients compared to controls (26.48 +/- 6.44 vs 30.42 +/- 7.92 ng/mL, P<0.001). There was an insignificant increase in serum adropin level in AMD patients (6.17 +/- 1-3.19 vs 5.79 +/- 2.71 ng/mL, P=0.4). Serum level of VEGFR-2 in AMD patients had a significant negative correlation with fovea! retinal thickness (r=-0.226, P=0.025) and a significant positive correlation with subfoveal choroidal thickness (r=0.2, P=0.048). CONCLUSION: The current study demonstrated that the decreased serum VEGFR-2 level may be considered in the development of AMD. Adropin does not seem to play a role in the pathogenesis of AMD.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage560en_US
dc.identifier.issn2222-3959
dc.identifier.issn2227-4898
dc.identifier.issue4en_US
dc.identifier.pmid27162728
dc.identifier.scopus2-s2.0-84964904346
dc.identifier.scopusqualityQ2
dc.identifier.startpage556en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6588
dc.identifier.volume9en_US
dc.identifier.wosWOS:000374276600013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIjo Pressen_US
dc.relation.ispartofInternational Journal Of Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectvascular endothelial growth factor receptor-2en_US
dc.subjectadropinen_US
dc.subjectage-related macular degenerationen_US
dc.titleSerum vascular endothelial growth factor receptor-2 and adropin levels in age-related macular degenerationen_US
dc.typeArticle

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