Intratympanic methylprednisolone for sudden sensorineural hearing loss

Basit Öğe Kaydı
dc.contributor.authorKılıç, Rahmi
dc.contributor.authorSafak, Mustafa Asim
dc.contributor.authorOguz, Haldun
dc.contributor.authorKargin, Selda
dc.contributor.authorDemirci, Munir
dc.contributor.authorSamim, Erdal
dc.contributor.authorOzluoglu, Levent Naci
dc.date.accessioned2020-06-25T17:43:53Z
dc.date.available2020-06-25T17:43:53Z
dc.date.issued2007
dc.descriptionKaytez, Selda Kargin/0000-0002-8683-7076; OZLUOGLU, LEVENT NACI/0000-0002-2150-0237
dc.description.abstractObjective: Corticosteroids are commonly used for the treatment of sudden sensorineural hearing loss (SSHL). In this study, the effectiveness of intratympanic (IT) corticosteroid injection was studied and compared with a control group on patients with SSHL who failed systemic corticosteroid treatment. Materials and Methods: A total of 19 patients as a retreatment group (RG) and 18 patients as a control group (CG), all failed high-dose intravenous and oral corticosteroid treatments, were included in this study. These patients were invited back, and IT methylprednisolone was injected five times via 3-day intervals in RG and followed-up for a mean period of 24.9 months (range, 7-30 mo). Audiological evaluations were performed initially, a week after the completion of the injections, monthly in the following first 3 months, and at the end of follow-up period in RG. The CG was followed-up for 3 months after the completion of systemic corticosteroid treatment without any additional drug administration. Results: The mean age was 52.6 years (range, 20-79 yr) in RG and 59.9 years in CG. The mean pure-tone average for speech frequencies (500-4,000 Hz) at baseline audiogram and at the first month, at the third month, and at last controls were 65.2 (range, 43-102 dB), 45.4 (range, 23-77 dB), 43.6 (range, 30-77 dB), and 44.5 (range, 33-77 dB) dB, respectively, in RG. The mean pure-tone averages for speech frequencies (500-4,000 Hz) at the end of systemic treatment and at third-month control were 63.5 (range, 44-98 dB) and 59.0 (range, 40-100 dB) dB, respectively, in CG. The hearing gain that is equal to or more than 10 dB was achieved in 14 patients (73.6%) at the last control in RG. No hearing gain could be detected in the CG. No serious side effect was observed with IT treatment. Conclusion: We conclude that IT methylprednisolone injection provides more significant hearing improvement for patients that failed with previous high-dose systemic corticosteroid administration than systemic corticosteroid treatment alone. So it may be the first-step medical treatment of idiopathic SSHL alone or at least may be combined with the systemic corticosteroid administration.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/MAO.0b013e31802fba7a
dc.identifier.endpage316en_US
dc.identifier.issn1531-7129
dc.identifier.issn1537-4505
dc.identifier.issue3en_US
dc.identifier.pmid17414035
dc.identifier.scopus2-s2.0-34247216692
dc.identifier.scopusqualityQ2
dc.identifier.startpage312en_US
dc.identifier.urihttps://doi.org10.1097/MAO.0b013e31802fba7a
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3936
dc.identifier.volume28en_US
dc.identifier.wosWOS:000245401500004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofOtology & Neurotology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcorticosteroiden_US
dc.subjectintratympanicen_US
dc.subjectsudden heating lossen_US
dc.subjecttreatmenten_US
dc.titleIntratympanic methylprednisolone for sudden sensorineural hearing lossen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Intratympanic methylprednisolone for sudden sensorineural hearing loss.pdf
Boyut:
106.6 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu