Evaluation of the toxicity of onyx compared with n-butyl 2-cyanoacrylate in the subarachnoid space of a rabbit model: an experimental research

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dc.contributor.authorBakar, Bulent
dc.contributor.authorOruckaptan, Hakan H.
dc.contributor.authorHazer, Burcu D.
dc.contributor.authorSaatci, Isil
dc.contributor.authorAtilla, Pergin
dc.contributor.authorKilic, Kamer
dc.contributor.authorMuftuoglu, Sevda F.
dc.date.accessioned2020-06-25T17:51:19Z
dc.date.available2020-06-25T17:51:19Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionATILLA, PERGIN/0000-0001-5132-0002
dc.description.abstractThe toxic effects of onyx, its solvent dimethyl sulphoxide (DMSO), and n-butyl 2-cyanoacrylate (NBCA) were evaluated after infusion into the subaracnoid space of a rabbit model. Each of the two various concentrations of onyx, pure DMSO, NBCA, and normal saline solution were percutaneously infused into the pontocerebellar cisternae of 39 domestic male albino rabbits, after which, the brain stems and medial cerebellar tissues were harvested for biochemical and histopathological studies. The specimens infused in various concentration of onyx, DMSO, and NBCA showed neural tissue necrosis and edema with inflammatory cell infitration in the acute stage. Although the mean values of the lipid peroxidase in the control, saline, and NBCA groups were found to be almost similar, they were found to be low in the onyx and DMSO groups. This experimental study suggests that NBCA, and various concentrations of onyx and DMSO have toxic effects on the neural tissues of rabbits when infused into the subarachnoid space.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00234-009-0594-8
dc.identifier.endpage134en_US
dc.identifier.issn0028-3940
dc.identifier.issue2en_US
dc.identifier.pmid19756562
dc.identifier.scopus2-s2.0-77749249442
dc.identifier.scopusqualityQ2
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.1007/s00234-009-0594-8
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4803
dc.identifier.volume52en_US
dc.identifier.wosWOS:000273950500007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofNeuroradiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOnyxen_US
dc.subjectDMSOen_US
dc.subjectNBCAen_US
dc.subjectToxicityen_US
dc.subjectSubarachnoiden_US
dc.titleEvaluation of the toxicity of onyx compared with n-butyl 2-cyanoacrylate in the subarachnoid space of a rabbit model: an experimental researchen_US
dc.typeArticle

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