Evaluation of pheniramine maleate and zofenopril in reducing renal damage induced by unilateral ureter obstruction. An experimental study

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dc.authoridYUVANC, ERCAN/0000-0002-5822-6972
dc.authoridTuglu, Devrim/0000-0002-4595-6298
dc.contributor.authorYuvanc, Ercan
dc.contributor.authorTuglu, Devrim
dc.contributor.authorOzan, Tunc
dc.contributor.authorKisa, Ucler
dc.contributor.authorBalci, Mahi
dc.contributor.authorBatislam, Ertan
dc.contributor.authorYilmaz, Erdal
dc.date.accessioned2025-01-21T16:40:41Z
dc.date.available2025-01-21T16:40:41Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction: Obstruction of the ureter may occur due to congenital, iatro-genic or other reasons. This can cause hydronephrosis in the early stage and can lead to cellular inflammation, necrosis and atrophy in the kidney tissue. The aim of this paper is to evaluate the protective effect of pheniramine maleate (PM) and zofenopril on renal damage caused by hydronephrosis due to unilateral partial ureter obstruction. Material and methods: Twenty-four female Sprague Dawley rats were divided into 4 groups. Group 1: sham group, group 2: partial unilateral ureteral obstruction (PUUO) group, group 3: PUUO + PM group, group 4: PUUO + zofenopril group. Paraoxonase (PON), total antioxidant status (TAS) and total oxidant status (TOS) of tissue and blood samples were measured and calculated. Tissue samples were evaluated histopathologically. Results: An increase in tissue TAS and a decrease in tissue TOS and OSI levels were detected in groups 3 and 4 compared to group 2 (both: p < 0.01). Tissue PON levels showed an increase in groups 3 and 4 compared to groups 1 and 2 (both: p < 0.01). Histopathological evaluation showed a decrease in interstitial inflammation and congestion in groups 3 and 4 compared to the control group (p < 0.001). The decrease was observed to be more significant in group 4 compared to group 3 (p < 0.01). Conclusions: In our experimental study, we observed that PM and zofenopril reduce the oxidation and tissue damage caused by unilateral partial obstruction.
dc.identifier.doi10.5114/aoms.2019.88320
dc.identifier.endpage817
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue3
dc.identifier.pmid34025852
dc.identifier.scopus2-s2.0-85106270161
dc.identifier.scopusqualityQ1
dc.identifier.startpage812
dc.identifier.urihttps://doi.org/10.5114/aoms.2019.88320
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24745
dc.identifier.volume17
dc.identifier.wosWOS:000680475600026
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofArchives of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectkidney; partial unilateral ureter obstruction; hydronephrosis; pheniramine maleate; zofenopril; total antioxidant capacity; total oxidant status; oxidative stress index; paraoxonase
dc.titleEvaluation of pheniramine maleate and zofenopril in reducing renal damage induced by unilateral ureter obstruction. An experimental study
dc.typeArticle

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