Evaluation of effects of curcumin on acute esophagitis in the corrosive esophagitis model in rats

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dc.authoridMUDERRISOGLU, AHMET/0000-0003-2954-360X
dc.authoridER, Zafer Cengiz/0000-0001-7129-1157
dc.contributor.authorGurlek, Ismail K.
dc.contributor.authorMuderrisoglu, Ahmet
dc.contributor.authorEr, Zafer C.
dc.contributor.authorArici, Akgul
dc.contributor.authorKupeli, Mustafa
dc.date.accessioned2025-01-21T16:40:38Z
dc.date.available2025-01-21T16:40:38Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIngestion of a corrosive substance may cause corrosive esophagitis. Curcumin has anti-inflammatory and mucosal protective effects. In this study, the effects of curcumin on the acute phase of corrosive esophagitis were investigated. Twenty-seven Wistar Albino rats were divided into four groups; sham (group I), control (group II), and experiment groups (group III, 100 mg/kg curcumin; group IV, 200 mg/kg curcumin). Forty percent sodium hydroxide solution was used to erode the esophagi of rats in groups other than the sham group. Curcumin was applied to animals in the experiment groups 10 min after the corrosion. After 24 h, animals were sacrificed, and esophagus samples were collected. According to the histopathological examination, the muscularis mucosa damage was regressed from 100% in group II to 71.4% in group III and 50% in group IV. Mild level of damage and collagen deposition in the tunica muscularis regressed from 66.7% of the animals in the control group to 42.9% in group III and to none in group IV. Further, an increase in submucosal collagen was present in all samples from groups II and III, while 83.3% of samples had an increase in submucosal collagen in group IV. There was a significant difference in the histopathological total score between the control group and group IV (p=0.02). The results showed that the administration of curcumin in a dose-dependent manner can relieve the acute phase of corrosive esophagitis.
dc.description.sponsorshipKirikkale University
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.1007/s00210-024-03038-2
dc.identifier.endpage6683
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue9
dc.identifier.pmid38498056
dc.identifier.scopus2-s2.0-85188105763
dc.identifier.scopusqualityQ2
dc.identifier.startpage6677
dc.identifier.urihttps://doi.org/10.1007/s00210-024-03038-2
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24730
dc.identifier.volume397
dc.identifier.wosWOS:001187125500006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBurns; Corrosion; Curcumin; Esophagitis; Inflammation
dc.titleEvaluation of effects of curcumin on acute esophagitis in the corrosive esophagitis model in rats
dc.typeArticle

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