Association Between Prognostic Nutritional Index and Bone Mineral Density, Fracture Risk Assessment (FRAX) Tool, and Disability in Patients with Postmenopausal Osteopenia/Osteoporosis: A Cross-Sectional Study

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dc.contributor.authorBaday-Keskin, Dilek
dc.contributor.authorHepsen, Sema
dc.contributor.authorUz, Cuma
dc.date.accessioned2025-01-21T16:34:12Z
dc.date.available2025-01-21T16:34:12Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: To evaluate the relationship between prognostic nutritional index (PNI) and bone mineral density (BMD) values and disability in patients with osteo penia /oste oporo sis. Methods: Between January 2022 and January 2023, 106 postmenopausal women with osteopenia (n = 54) and osteoporosis (n = 52) were included in the study. Patients with a disease or medication causing secondary osteoporosis were excluded. Bone mineral density was evaluated using dual- energy X-ray absorptiometry. Nutritional status was measured using the PNI, which was calculated using total lymphocyte count and serum albumin levels. The Health Assessment Questionnaire Disability Index (HAQ-DI) was used to evaluate disability. Results: The mean age of the participants was 63.78 +/- 7.53 years. Prognostic nutritional index was positively correlated with total hip BMD values (r r = 0.217, P = .029) and total hip T-scores (r r = 0.207, P = .037) and negatively correlated with Fracture Assessment Tool Model (FRAX)-major fracture risk (r r = - 0.399, P < .001), FRAX-hip fracture risk (r r = - 0.300, P = .002), and HAQ-DI scores (r r =--0.474, - 0.474, P < .001). The mean PNI was lower in patients with a history of falls than in those without falls (P P < .001). The mean PNI was lower in patients with a history of osteoporotic fractures than in those without a fracture history (P P = .007). Multivariate linear regression analyses showed that PNI was the only independent variable for HAQ-DI (B B = - 0.040, P < .001) (R2 R2 = 0.17). Conclusion: Using PNI in clinical practice may be beneficial because of its association with BMD values and for predicting the independence of patients with osteo penia /oste oporo sis. If a disability is detected, a multidisciplinary approach should be considered, including rehabilitation and improvement of nutritional condition.
dc.identifier.doi10.5152/erp.2024.24438
dc.identifier.endpage150
dc.identifier.issn2822-6135
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85199135461
dc.identifier.scopusqualityQ4
dc.identifier.startpage143
dc.identifier.trdizinid1275555
dc.identifier.urihttps://doi.org/10.5152/erp.2024.24438
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1275555
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23907
dc.identifier.volume28
dc.identifier.wosWOS:001267516900003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAves
dc.relation.ispartofEndocrinology Research and Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBone mineral density; Ca metabolism; osteoporosis and metabolic bone diseases; disability; FRAX; prognostic nutritional index
dc.titleAssociation Between Prognostic Nutritional Index and Bone Mineral Density, Fracture Risk Assessment (FRAX) Tool, and Disability in Patients with Postmenopausal Osteopenia/Osteoporosis: A Cross-Sectional Study
dc.typeArticle

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