Valproic acid in prophylaxis of refractory migraine

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dc.contributor.authorErdemoglu, AK
dc.contributor.authorOzbakir, S
dc.date.accessioned2020-06-25T17:34:40Z
dc.date.available2020-06-25T17:34:40Z
dc.date.issued2000
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective - The efficacy and safety of valproic acid were assessed as a prophylactic agent in migraine patients who previously derived no significant benefit from conventional prophylactic medications for migraine. Patients and methods - One hundred and twenty patients aged 23-58 years with the diagnosis of migraine without aura. Response to therapy was determined by using a headache calendar detailing the frequency and severity of attacks. Reduction of 50% or greater in the frequency or severity of headache was considered as improvement. Results - Improvement was observed in headache frequency within 67% of patients. Headache severity had been improved in 60% of patients. The mean average dosage of valproic acid was 1250 mg daily. Most of the side effects are mild and tolerable. Conclusion - These results suggest that valproic acid is effective and safe in the treatment of refractory migraine headache.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage358en_US
dc.identifier.issn0001-6314
dc.identifier.issn1600-0404
dc.identifier.issue6en_US
dc.identifier.pmid11125749
dc.identifier.scopus2-s2.0-0033712673
dc.identifier.scopusqualityQ1
dc.identifier.startpage354en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2834
dc.identifier.volume102en_US
dc.identifier.wosWOS:000165593800004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofActa Neurologica Scandinavica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectvalproic aciden_US
dc.subjectmigraineen_US
dc.subjectrefractory headacheen_US
dc.subjecttreatmenten_US
dc.subjectprophylaxisen_US
dc.titleValproic acid in prophylaxis of refractory migraineen_US
dc.typeArticle

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