Can Dehydroepiandrosterone-Sulphate be a New Diagnostic Parameter in Idiopathic Hypogonadotropic Hypogonadism?

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dc.authoridÇarlıoğlu, Ayşe/0000-0002-5622-9563
dc.contributor.authorÇadırcı, Kenan
dc.contributor.authorKeskin, Havva
dc.contributor.authorBayrak, Muharrem
dc.contributor.authorÇarlıoğlu, Ayşe
dc.contributor.authorCeylan Arıkan, Senay
dc.date.accessioned2025-01-21T16:33:37Z
dc.date.available2025-01-21T16:33:37Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEA-sulfate (DHEA-s) are major androgen hormones which are synthesis from the adrenal origin. The purpose of this study was to investigate DHEA-s levels in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and to determine whether DHEA-s level are a useful marker for diagnosis of IHH.Methods: A total of 91 subjects, 31 males with IHH (mean age 19.7 +/- 2.6 years) and 60 healthy males (mean age 20.7 +/- 2.6 years), were enrolled in this study. The patients with IHH were selected from the subjects who had not yet started treatment for hypogonadism and who had no additional disease, while the healthy control group consisted entirely from individuals admitted to the same hospital outpatient clinic for routine check-ups. Both groups' blood sampling, anthropometric measures, and physical examination were undertakenResults: Mean DHEA-s level was 133.4 +/- 56.5 mu g/dL in the IHH group and 433.3 +/- 160.3 mu g/dL in the control group (p=0.000). The low DHEA-s level in patients with IHH was independent of age, cortisol, and adrenocorticotropic hormone (ACTH) at multivariate logistic regression analysis. The ROC analysis showed that DHEA-s <= 38.2 mu g/dL supports a diagnosis of IHH with 100% specificity and 100% sensitivity. DHEA-s was as predictive as total testosterone which is used in the diagnosis of patients with IHH.Conclusion: DHEA-s level was significantly lower in the males with IHH compared to controls. Therefore, DHEA-s may be a potential predictive marker for diagnosis of IHH.
dc.identifier.doi10.14235/bas.galenos.2021.6094
dc.identifier.endpage632
dc.identifier.issn2148-2373
dc.identifier.issue5
dc.identifier.startpage628
dc.identifier.trdizinid1173766
dc.identifier.urihttps://doi.org/10.14235/bas.galenos.2021.6094
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1173766
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23817
dc.identifier.volume10
dc.identifier.wosWOS:000877834200014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofBezmialem Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectDehydroepiandrosterone; dehydroepiandrosterone-sulphate; idiopathic hypogonadotropic hypogonadism
dc.titleCan Dehydroepiandrosterone-Sulphate be a New Diagnostic Parameter in Idiopathic Hypogonadotropic Hypogonadism?
dc.typeArticle

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