Effect of Naloxone on Oxidative Stress and Testicular Injury due to Spermatic Vessel Ligation of Rat Testis

Basit Öğe Kaydı
dc.contributor.authorCakan, Murat
dc.contributor.authorYilmazer, Demet
dc.contributor.authorCakan, Turkay
dc.contributor.authorAydos, Tolga R.
dc.contributor.authorOgus, Elmas
dc.contributor.authorKilinc, Aytun S.
dc.contributor.authorAltug, Ugur
dc.date.accessioned2020-06-25T17:48:07Z
dc.date.available2020-06-25T17:48:07Z
dc.date.issued2008
dc.descriptionaltug, mustafa ugur/0000-0002-6475-2178; Aydos, Tolga Resat/0000-0002-1832-9336
dc.description.abstractAims: Two-stage Fowler-Stephens orchiopexy has been accompanied by testicular atrophy in some cases but neither of the mechanisms responsible for testicular injury are clear, nor is there an effective agent that might prevent this injury. In this study we aimed to investigate the long-term effects of naloxone, a morphine antagonist, on testicular histopathology and oxidative stress after spermatic vessel ligation (SVL) in rats. Methods: 32 prepubertal rats were randomly divided into four equal groups: group 1: control (only bilateral orchiectomies were performed); group 2: sham-operated group; group 3: SVL, and group 4: SVL+naloxone (1 mg/kg twice daily for 1 month). One month postoperatively, bilateral orchiectomies were performed to evaluate histopathologic findings and measurement of malondialdehyde (MDA) and nitric oxide (NO) levels. Results: Considering group 3, left SVL resulted in significant tissue damage in both testes, more severe in the ipsilateral testis. The SVL resulted in a significant increase in testicular MDA levels of both testes in this group (p < 0.05). While the ipsilateral testicular NO levels of groups 2 and 3 were significantly lower than of group 1 (p < 0.05), the contralateral testicular NO levels of all these groups were similar. After naloxone therapy, while there was no significant improvement in ipsilateral testicular histopathology (p > 0.05), the contralateral testicular histopathology improved significantly (p < 0.05). However, naloxone did not change either testicular MDA or NO levels. Conclusions: The SVL led to bilateral testicular injury, and oxidative stress may be a reason for this injury. Naloxone significantly improved contralateral testicular injury without showing any antioxidative effect. Copyright (c) 2008 S. Karger AG, Baselen_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1159/000151404
dc.identifier.endpage284en_US
dc.identifier.issn0042-1138
dc.identifier.issue3en_US
dc.identifier.pmid18931543
dc.identifier.scopus2-s2.0-54249110988
dc.identifier.scopusqualityQ2
dc.identifier.startpage279en_US
dc.identifier.urihttps://doi.org10.1159/000151404
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4312
dc.identifier.volume81en_US
dc.identifier.wosWOS:000260236500007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpermatic vessel ligationen_US
dc.subjectOxidative stressen_US
dc.subjectTesticular injuryen_US
dc.subjectRat testisen_US
dc.subjectNaloxoneen_US
dc.titleEffect of Naloxone on Oxidative Stress and Testicular Injury due to Spermatic Vessel Ligation of Rat Testisen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Effect of Naloxone on Oxidative Stress and Testicular Injury due to Spermatic Vessel Ligation of Rat Testis.pdf
Boyut:
374.96 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu