The effects of iloprost on lung injury induced by skeletal muscle ischemia-reperfusion

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dc.contributor.authorErer, D.
dc.contributor.authorDursun, A. D.
dc.contributor.authorOktar, G. L.
dc.contributor.authorIriz, E.
dc.contributor.authorZor, M. H.
dc.contributor.authorElmas, C.
dc.contributor.authorArslan, M.
dc.date.accessioned2020-06-25T18:12:26Z
dc.date.available2020-06-25T18:12:26Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063; DURSUN, ALI DOGAN/0000-0001-9056-0025
dc.description.abstractPurpose: The aim of this study was to investigate the effects of iloprost (I) on lung injury as a remote organ following skeletal muscle ischemia-reperfusion injury in a rat model. Materials and methods: Twenty-four Wistar Albino rats were randomized into four groups (n = 6). Laparotomy was performed in all groups under general anesthesia. Only laparotomy was applied in Group S (Sham). Ischemia reperfusion group (Group I/R) underwent ischemia and reperfusion performed by clamping and declamping of the infrarenal abdominal aorta for 120 minutes. Group iloprost (Group 1) received intravenous infusion of iloprost 0.5 ng/kg/min, without ischemia and reperfusion. Group I/R/I received intravenous infusion of iloprost 0.5 ng/kg/min immediately after 2 hours of ischemia. At the end of the study, lung tissue was obtained for determining total oxidant status (TOS) and total antioxidant status (TAS) levels, histochemical and immunohistochemical determination. Results: Diffuse lymphocyte infiltration was detected in immunohistochemical examination of lung tissue in Group I/R. The connective tissue around bronchi, bronchioles and vessel walls was found to be increased. Although minimal local lymphocyte infiltration was detected in some fields in Group I/R/I, the overall tissue was found to be similar to Group S. iNOS expression was significantly higher in Group I/R, when compared with Group S and significantly lower in Group I/R/I compared to Group I/R. TOS levels were significantly higher in Group I/R, when compared with groups S and I (p = 0.028, p = 0.016, respectively) and significantly lower in group I/R/I, when compared with Group I/R (p = 0.048). TAS levels were significantly higher in Group I/R, when compared with groups S, I (p = 0.014, p = 0.027, respectively) and significantly lower in Group I/R/I, when compared with Group I/R (p = 0.032). Conclusion: These results indicate that administration of iloprost may have protective effects against ischemia reperfusion injury (Fig. 8, Tab. 1, Ref. 30). Text in PDF www.elis.sk.en_US
dc.identifier.citationErer, D., Dursun, A. D., Oktar, G. L., Iriz, E., Zor, M. H., Elmas, Ç., ... Donmez, T.(2014). The effects of iloprost on lung injury induced by skeletal muscle ischemia-reperfusion. BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 115(7), 405-410.en_US
dc.identifier.doi10.4149/BLL_2014_080
dc.identifier.endpage410en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue7en_US
dc.identifier.pmid25077362
dc.identifier.scopus2-s2.0-84905993633
dc.identifier.scopusqualityQ2
dc.identifier.startpage405en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_080
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5913
dc.identifier.volume115en_US
dc.identifier.wosWOS:000340863400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectischemia-reperfusionen_US
dc.subjecttotal oxidant statusen_US
dc.subjecttotal antioxidant statusen_US
dc.subjectiloprosten_US
dc.subjectiNOSen_US
dc.subjectlung tissueen_US
dc.subjectraten_US
dc.titleThe effects of iloprost on lung injury induced by skeletal muscle ischemia-reperfusionen_US
dc.typeArticle

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