Effects of Recurrent Sevoflurane Anesthesia on Erythrocyte Deformability in Experimentally Induced Alzheimer Rats

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dc.authoridOZTURK, LEVENT/0000-0001-9755-033X
dc.authoridDuruk Erkent, Fatma Nur/0000-0002-9161-5013
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorGuney, Sevin
dc.contributor.authorErkent, Fatmanur Duruk
dc.contributor.authorIsik, Berrin
dc.contributor.authorOzturk, Levent
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2025-01-21T16:33:05Z
dc.date.available2025-01-21T16:33:05Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description1st International Hippocrates Congress of Hippocrat Medicine and Health Sciences -- MAR 01-03, 2019 -- Ankara, TURKEY
dc.description.abstractObjectives: The aim of this study was to investigate the association between Alzheimer's disease and erythrocyte deformability and to assess whether recurrent sevoflurane anesthesia influenced this association. Methods: A total of 24 Wistar albino rats were divided into four groups: Control, sevoflurane, Alzheimer, and Alzheimer + sevoflurane. The experimental Alzheimer model was prepared by intracerebroventricular injection of streptozotocin at a dose of 3 mg/kg (10 mu l) to the Alzheimer and Alzheimer + sevoflurane groups. Sevoflurane (2.3%) was administered to the sevoflurane and Alzheimer + sevoflurane groups 4 weeks after the surgery for 3 days and lasting for 2 hours per day. Blood samples were then collected for deformability measurements. Results: The deformability index was significantly increased in Alzheimer-induced rats, but the results for the Alzheimer and Alzheimer + sevoflurane groups were similar. The erythrocyte deformability index was significantly increased in the Alzheimer and Alzheimer + sevoflurane groups (p=0.004 p=0.001 respectively). However, there was no difference in deformability in the sevoflurane group (p= 0.496) Conclusion: Erythrocyte deformability was increased in the Alzheimer-induced rats; however recurrent sevoflurane anesthesia did not affect erythrocyte deformability.
dc.identifier.doi10.12996/gmj.2022.06
dc.identifier.endpage28
dc.identifier.issn2147-2092
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85122575726
dc.identifier.scopusqualityQ4
dc.identifier.startpage25
dc.identifier.urihttps://doi.org/10.12996/gmj.2022.06
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23712
dc.identifier.volume33
dc.identifier.wosWOS:000733303100005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGazi Univ, Fac Med
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAlzheimer disease; erythrocyte deformability; sevoflurane; rat; animal models experimental
dc.titleEffects of Recurrent Sevoflurane Anesthesia on Erythrocyte Deformability in Experimentally Induced Alzheimer Rats
dc.title.alternativeDeneysel Alzheimer Oluşturulmuş Yaşlı Ratlarda Tekrarlayan Sevofluran Anestezisinin Eritrosit Deformabilitesi Üzerine Etkisinin Değerlendirilmesi
dc.typeConference Object

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