Molecular characterization of rotaviruses in mid-western Turkey, 2006-2007

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dc.contributor.authorAltındiş, Mustafa
dc.contributor.authorBanyai, Krisztian
dc.contributor.authorKalayci, Raike
dc.contributor.authorGülamber, Cihangir
dc.contributor.authorKöken, Resit
dc.contributor.authorApan, Teoman
dc.contributor.authorAykurt, Pınar
dc.date.accessioned2020-06-25T17:49:09Z
dc.date.available2020-06-25T17:49:09Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionAltindis, Mustafa/0000-0003-0411-9669; Banyai, Krisztian/0000-0002-6270-1772
dc.description.abstractVaccines against rotaviruses are now available in numerous countries, including Turkey. As the vaccines may show various efficiencies against different type specificities and routine vaccination in infants might result in selection and immune escape of wild-type rotavirus strains, strain surveillance has been initiated before and during the vaccine introduction. We aimed to provide corresponding information on local strain prevalence in Anatolia, mid-western Turkey during the introduction of rotavirus vaccines. Stool samples positive for group A rotavirus by commercial enzyme immunoassay were subjected to reverse transcription-polymerase chain reaction based genotyping of the outer capsid antigens, VP7 and VP4, determining G and P type specificities respectively. Among 36 fully and 5 partially typeable strains we detected genotype G1, G2, and G9 VP7 specificities and genotype P[4], P[6] and P[8] VP4 specificities in 5 individual and 4 mixed combinations. The most common strain was G2P[4] (n=17), followed by G9P[8] (n=9). Other strains were G1P[8] (n=2), G2P[8] (n=2), G1+2P[8] (n=2), G9P[4] (n=1), G2+9P[8] (n=1), G4+9P[6] (n=1), and G2P[4+8] (n=1). Partially typed strains included 2 G1P[NT] and 3 G2P[NT] strains. Our data may help determine a baseline of the rotavirus genotype prevalence in Turkey and see if changes in the incidence of individual strains will be observed after routine use of vaccine.en_US
dc.description.sponsorshipHungarian Scientific Research Fund (OTKA)Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [T049020]en_US
dc.description.sponsorshipWe would like to thank Dr Ahmet Gayretli for his contributions to improve the paper. The helpful remarks of the anonymous Reviewer of our paper are also acknowledged. The study was supported in part by the Hungarian Scientific Research Fund (OTKA, T049020).en_US
dc.identifier.citationAltindis, M., Bányai, K., Kalayci, R., Gulamber, C., Koken, R., Apan, T., Koçoğlu, E., Bukulmez, A., Yoldas, Y. & Aykurt, P. (2010). Molecular characterization of rotaviruses in mid-western Turkey, 2006–2007. Open Medicine, 5(5), 640-645. https://doi.org/10.2478/s11536-009-0130-6en_US
dc.identifier.doi10.2478/s11536-009-0130-6
dc.identifier.endpage645en_US
dc.identifier.issn1895-1058
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-77956064187
dc.identifier.scopusqualityN/A
dc.identifier.startpage640en_US
dc.identifier.urihttps://doi.org/10.2478/s11536-009-0130-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4648
dc.identifier.volume5en_US
dc.identifier.wosWOS:000285418300019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherVersitaen_US
dc.relation.ispartofCentral European Journal Of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRotavirusen_US
dc.subjectGenotypingen_US
dc.subjectVP7en_US
dc.subjectVP4en_US
dc.subjectReassortmenten_US
dc.subjectVaccineen_US
dc.titleMolecular characterization of rotaviruses in mid-western Turkey, 2006-2007en_US
dc.typeArticle

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