The effects of amantadine on lung tissue in lower limb ischemia/reperfusion injury model in rats

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dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.authoridTas Tuna, Ayca/0000-0001-6764-2647
dc.authoridIrmak Gozukara, Sezen/0000-0002-4825-4611
dc.contributor.authorOrhan, Mustafa
dc.contributor.authorTuna, Ayca Tas
dc.contributor.authorUnal, Yusuf
dc.contributor.authorArslan, Mustafa
dc.contributor.authorYazar, Hayrullah
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorGozukara, Sezen Irmak
dc.date.accessioned2025-01-21T16:45:23Z
dc.date.available2025-01-21T16:45:23Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: This study aims to evaluate the effect of amantadine on lung tissue of after lower limb ischemia/reperfusion injury in rats. Methods: A total of 24 Wistar rats were divided into four equal groups including six rats in each: sham group (Group S), amantadine group (Group A), ischemia/reperfusion group (Group I/R), and ischemia/reperfusion + amantadine group (Group I/R-A). All groups underwent a midline abdominal incision. In Groups I/R and I/R-A, the infrarenal abdominal aorta was clamped for 120 min and, then, reperfused for 120 min after removal of the clamp. Amantadine hydrochloride 45 mg/kg was administered intraperitoneally to the rats of Groups A and Group I/R-A 15 min before surgery. At the end of reperfusion period (240 min), all rats were sacrificed, and their lung tissues were obtained. Lung tissue catalase and superoxide dismutase activities and glutathione S-transferase and malondialdehyde levels were analyzed. Lung tissues were examined histopathologically. Results: Catalase activity was lower in Groups A, I/R, and I/R-A compared to Group S. Superoxide dismutase activity was higher in Group I/R than Group S. Superoxide dismutase activity in Groups I/R-A and A decreased, compared to Groups S and I/R. Glutathione S-transferase levels decreased in Groups I/R and A, compared to Group S. Glutathione S-transferase levels in Group I/R-A were higher than Groups I/R and A. The highest level of malondialdehyde was found in Group I/R and the lowest level was found in Group I/R-A. According to histopathological examination, infiltration scores were significantly lower in Group S than Groups I/R and I/R-A (p=0.009 and p=0.011, respectively). The alveolar wall thickening scores in Group I/R were also significantly higher than Groups S and Group A (p=0.001 and p=0.001, respectively). Conclusion: Lung tissue can be affected histopathologically by ischemia/ reperfusion injury and this injury can be reversed by amantadine administration.
dc.identifier.doi10.5606/tgkdc.dergisi.2021.19884
dc.identifier.endpage84
dc.identifier.issn1301-5680
dc.identifier.issue1
dc.identifier.pmid33768984
dc.identifier.scopus2-s2.0-85101554966
dc.identifier.scopusqualityQ3
dc.identifier.startpage78
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2021.19884
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25631
dc.identifier.volume29
dc.identifier.wosWOS:000612350500011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayincilik
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAmantadine; ischemia/reperfusion; lower limb; lung
dc.titleThe effects of amantadine on lung tissue in lower limb ischemia/reperfusion injury model in rats
dc.title.alternativeAmantadinin alt ekstremite iskemi/reperfüzyon sıçan modelinde akciğer dokusu üzerindeki etkileri
dc.typeArticle

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