Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome

Basit Öğe Kaydı
dc.contributor.authorGuzelkas, Ismail
dc.contributor.authorOrbak, Zerrin
dc.contributor.authorDoneray, Hakan
dc.contributor.authorOzturk, Nurinnisa
dc.contributor.authorSagsoz, Nevin
dc.date.accessioned2025-01-21T16:44:22Z
dc.date.available2025-01-21T16:44:22Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction, clinical and/or biochemical hyperandrogenism, and polycystic ovaries. Its pathogenesis is still unclear. This study aimed to investigate the relationship between kisspeptin, leptin, neuropeptide Y (NPY), and neurokinin B (NKB) levels for evaluating the pathogenesis of PCOS. Methods Levels of these parameters were analyzed in 20 patients with PCOS, and 16 healthy adolescents. Results Serum NPY levels were significantly higher in the obese and non-obese PCOS group (p<0.01). There was a negative correlation between the kisspeptin and the NKB levels (p<0.01) in the PCOS group but not in the control group. This negative correlation was also found in both PCOS groups (p<0.01). In the obese PCOS group, serum kisspeptin levels were significantly lower than the control and non-obese PCOS groups (p<0.05) although serum leptin and NPY levels were significantly higher in the obese PCOS group (p<0.01). Conclusions The high NPY levels in both obese and non-obese patients with PCOS indicate that NPY plays a role in the pathogenesis independently from obesity. Significantly high leptin and low kisspeptin levels in the obese PCOS group suggested that they may be associated with obesity rather than PCOS.
dc.description.sponsorshipAtaturk University Scientific Research Projects Commission [TTU-2017-6272]
dc.description.sponsorshipThis work was supported by Ataturk University Scientific Research Projects Commission with the code TTU-2017-6272.
dc.identifier.doi10.1515/jpem-2021-0487
dc.identifier.endpage487
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue4
dc.identifier.pmid35170267
dc.identifier.scopus2-s2.0-85124821512
dc.identifier.scopusqualityQ2
dc.identifier.startpage481
dc.identifier.urihttps://doi.org/10.1515/jpem-2021-0487
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25441
dc.identifier.volume35
dc.identifier.wosWOS:000755533800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectadolescents; kisspeptin; leptin; neuropeptide Y and neurokinin B; polycysticovary syndrome
dc.titleSerum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu