Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion

Basit Öğe Kaydı
dc.contributor.authorOktar, G. L.
dc.contributor.authorKirisci, M.
dc.contributor.authorDursun, A. D.
dc.contributor.authorZor, M. H.
dc.contributor.authorIriz, E.
dc.contributor.authorErer, D.
dc.contributor.authorArslan, M.
dc.date.accessioned2020-06-25T18:07:33Z
dc.date.available2020-06-25T18:07:33Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063; DURSUN, ALI DOGAN/0000-0001-9056-0025
dc.description.abstractPurpose: The aim of this study was to investigate the effects of adrenomedullin (AM) and vascular endothelial growth factor (VEGF) on lung injury as a remote organ following skeletal muscle ischemia-reperfusion injury in a rat model. Materials and methods: Thirty-six Wistar rats were randomized into six groups (n=6). Laparotomy was performed in all groups under general anesthesia. Nothing else was done in Group S (Sham). Ischemia reperfusion group (Group I/R) underwent ischemia and reperfusion performed by clamping and declamping of the infrarenal abdominal aorta for 120 minutes, respectively. Group VEGF and Group AM received intravenous infusion of VEGF (0.8 mu g/kg) or AM (12 mu g/kg) respectively, without ischemia and reperfusion. Group IR+VEGF and Group IR+AM received intravenous infusion of VEGF (0.8 mu g/kg) or AM (12 mu g/kg) respectively immediately after 2 hours period of ischemia. At the end of reperfusion period. Lung tissue samples were taken for biochemical examination. Total oxidant status (TOS) and total antioxidant status (TAS) levels in lung tissue were determined by using a novel automated method. p<0.05 was considered as statistically significant. Results: TOS levels were significantly higher in Group I/R, when compared with groups S, AM and VEGF (p=0.004, p=0.011, p=0.017, respectively) and significantly lower in groups I/R+AM and I/R+VEGF, when compared with Group I/R (p=0.018, p=0.006, respectively). TAS levels were significantly higher in Group I/R, when compared with groups S, AM and VEGF (p=0.006 p=0.016, p=0.016, respectively) and significantly lower in Group I/R+AM, when compared with Group I/R (p=0.016). Conclusion: These findings indicate that AM and VEGF acted effectively on the prevention of lung injury induced by skeletal muscle ischemia-reperfusion injury in a rat model (Fig. 2, Ref. 30). Full Text in PDF www.elis.sk.en_US
dc.identifier.citationOktar, G. L., Kirisci, M., Dursun, A. D., Zor, M. H., Iriz, E., Erer, D., Comu, F. M., & Arslan, M. (2013). Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion. Bratislavske lekarske listy, 114(11), 625–628.en_US
dc.identifier.doi10.4149/BLL_2013_133
dc.identifier.endpage628en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue11en_US
dc.identifier.pmid24236430
dc.identifier.scopus2-s2.0-84890245008
dc.identifier.scopusqualityQ2
dc.identifier.startpage625en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2013_133
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5606
dc.identifier.volume114en_US
dc.identifier.wosWOS:000331063900005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectischemia-reperfusionen_US
dc.subjecttotal oxidant statusen_US
dc.subjecttotal antioxidant statusen_US
dc.subjectadrenomedullinen_US
dc.subjectvascular endothelial growth factoren_US
dc.subjectraten_US
dc.titleAntioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusionen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion.pdf
Boyut:
286.92 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

Kişisel bilgilerinizi şu amaçlarla toplar ve işleriz: Kimlik Doğrulama, Tercihler, Onay ve İstatistikler.
Daha fazla bilgi edinmek için lütfen gizlilik politikası sayfamızı okuyun.

Özelleştirme