Bilayer wound dressing composed of asymmetric polycaprolactone membrane and chitosan-carrageenan hydrogel incorporating storax balsam

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dc.authoridTezcaner, Ayşen/0000-0003-4292-5856
dc.contributor.authorNakipoglu, Mustafa
dc.contributor.authorÖzkabadayı, Yasin
dc.contributor.authorKarahan, Siyami
dc.contributor.authorTezcaner, Ayşen
dc.date.accessioned2025-01-21T16:36:10Z
dc.date.available2025-01-21T16:36:10Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractA comprehensive approach is needed to develop multifunctional wound dressing that is simple yet efficient. In this work, Liquidambar orientalis Mill. storax loaded hydroxyethyl chitosan (HECS)-carrageenan (kC) based hydrogel (HECS-kC) and polydopamine coated asymmetric polycaprolactone membrane (PCL-DOP) were used to develop a multifunctional and modular bilayer wound dressing. Asymmetric PCL-DOP membrane was prepared by non-solvent induced phase separation (NIPS) followed by polydopamine coating and demonstrated an excellent barrier against bacteria while allowing permeability for 5.45 ppm dissolved-oxygen and 2130 g/m2 water vapor transmission in 24 h in addition to 805 kPa tensile strength. Storax loaded HECS-kC hydrogel, on the other hand, demonstrated a pH-responsive degradation and swelling to provide necessary conditions to facilitate wound healing. The hydrogels showed stretchability above 140 %, mild adhesive strength on sheep skin and PCLDOP membrane, while the storax incorporation enhanced antibacterial and antioxidant activity. Furthermore, rat full-thickness skin defect model showed that the developed bilayer wound dressing could significantly facilitate wound healing compared to TegadermTM and control groups. This study shows that the bilayered wound dressing has the potential to be used as a simple and effective wound care system.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBIbull;TAK 222S018]
dc.description.sponsorshipFunding This work was partially funded by Scientific and Technological Research Council of Turkey under the grant number TUBIcenter dotTAK 222S018.
dc.identifier.doi10.1016/j.ijbiomac.2023.128020
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid37956814
dc.identifier.scopus2-s2.0-85181677047
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2023.128020
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24271
dc.identifier.volume254
dc.identifier.wosWOS:001121589300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectPolycaprolactone; Chitosan; Carrageenan; Liquidambar orientalis Mill.; Wound dressing
dc.titleBilayer wound dressing composed of asymmetric polycaprolactone membrane and chitosan-carrageenan hydrogel incorporating storax balsam
dc.typeArticle

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