Skin-homing T-cell responses associated with Demodex infestation and rosacea

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dc.contributor.authorGazi, Umut
dc.contributor.authorGureser, Ayse Semra
dc.contributor.authorOztekin, Aynure
dc.contributor.authorKarasartova, Djursun
dc.contributor.authorKosar-Acar, Nezahat
dc.contributor.authorDerici, Mehmet Kursat
dc.contributor.authorTaylan-Ozkan, Aysegul
dc.date.accessioned2020-06-25T18:33:59Z
dc.date.available2020-06-25T18:33:59Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionDerici, Mehmet Kursat/0000-0002-8260-7492; Ozkan, Aysegul Taylan/0000-0001-8421-3625
dc.description.abstractAims Our aim was to investigate the skin-homing T-cell immune responses triggered in patients with Demodex infestation and/or rosacea. Methods Collected whole blood samples were divided into four groups: control subjects; nonrosacea patients with Demodex infestation (Demodex group); papulopustular rosacea (PPR) patients without Demodex infestation (Rosacea group); and PPR patients with Demodex infestation (Rosacea/Demodex group). Following ex vivo activation, skin-homing CLA+CD4+ T-cell subset levels were monitored by flow cytometry. Results When compared with control subjects, among skin-homing CD4+ T-cell subsets analysed, Demodex patients had higher T(H)9 and T-reg cell levels; Rosacea subjects displayed elevated T(H)1 cell levels; and Rosacea/Demodex patients exhibited increased frequencies of T(H)9 and T(H)22 cells. In contrast to Rosacea subjects, Rosacea/Demodex group members displayed higher T(H)2 cell levels; and when compared with Demodex groups, they had higher T(H)1 and T(H)2 but lower T-reg cell levels. Demodex group members also exhibited higher T-reg but lower T(H)1 and T(H)22 levels than Rosacea/Demodex group subjects. Conclusions The skin-homing T-cell responses associated with Demodex infestation and rosacea formation seem to influence each other. The present as well as future studies could contribute to the development of effective treatment strategies for demodicosis and rosacea.en_US
dc.description.sponsorshipHitit University Scientific Research Projects UnitHitit University [TIP19002.16.005]en_US
dc.description.sponsorshipHitit University Scientific Research Projects Unit, Grant/Award Number: TIP19002.16.005en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/pim.12658
dc.identifier.issn0141-9838
dc.identifier.issn1365-3024
dc.identifier.issue8en_US
dc.identifier.pmid31125450
dc.identifier.scopus2-s2.0-85067468017
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/pim.12658
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7728
dc.identifier.volume41en_US
dc.identifier.wosWOS:000475958100003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofParasite Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD4+en_US
dc.subjectCLAen_US
dc.subjectDemodexen_US
dc.subjectrosaceaen_US
dc.subjectT cellsen_US
dc.titleSkin-homing T-cell responses associated with Demodex infestation and rosaceaen_US
dc.typeArticle

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