Effect of ondansetron for preventing of ovarian hyperstimulation syndrome: in an experimental rat model

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dc.authoridSahin, Yasar/0000-0001-5936-4210
dc.authoridsagsoz, nevin/0000-0002-9927-5877
dc.authoridGOZUYUKARI, Hilal/0000-0003-0282-2596
dc.contributor.authorBakirci, Suekrue
dc.contributor.authorSagsoez, Nevin
dc.contributor.authorDevrim, Tuba
dc.contributor.authorSahin, Yasar
dc.contributor.authorBulanik, Murat
dc.contributor.authorGoezueyukari, Hilal
dc.date.accessioned2025-01-21T16:37:59Z
dc.date.available2025-01-21T16:37:59Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Ovarian hyperstimulation syndrome is an iatrogenic condition that occurs in the treatment of infertility. There is no specific treatment available for OHSS. Cabergoline is a dopamine receptor 2 agonist and VEGF-VEGF2 receptor antagonist . Recently, cabergoline has been widely used to prevent the development of OHSS and reduce its severity Serotonin is known as a neurotransmitter and thought to have a role in the mechanism of angiogenesis and in signaling in endothelial cells. Serotonin is said to have similar effects to VEGF . Ondansetron is Selective Serotonin (5-HT3) Receptor Antagonist . It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. In the clinical practice today, there is no choice other than cabergoline, to prevent occurrence and reduce severity of OHSS, and sometimes its effects are limited. Methods: In our study, we compared the effect of cabergoline and ondansetron. 32 immature rats were used and the OHSS model was created. Parameters such as hematocrit value , ovarian size, the number of follicles in the ovary, endometrial capillary congestion and thickness values were evaluated and compared. Results: As a result, in our study, it was seen that ondansetron was effective on OHSS in many parameters. It is thought to be as effective as cabergoline. When we look at the literature, this is the first study in which ondansetron was evaluated for this purpose. It would be good to show this effect of ondansetron with other studies.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale University [2020/092]
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Kirikkale University. Project number 2020/092
dc.identifier.doi10.1080/09513590.2022.2163233
dc.identifier.endpage1096
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue12
dc.identifier.pmid36579847
dc.identifier.scopus2-s2.0-85145299864
dc.identifier.scopusqualityQ2
dc.identifier.startpage1093
dc.identifier.urihttps://doi.org/10.1080/09513590.2022.2163233
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24580
dc.identifier.volume38
dc.identifier.wosWOS:000905639200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectCabergoline; ondansetron; ovarian hyperstimulation syndrome; rat model
dc.titleEffect of ondansetron for preventing of ovarian hyperstimulation syndrome: in an experimental rat model
dc.typeArticle

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