Dexmedetomidine protects against lipid peroxidation and erythrocyte deformability alterations in experimental hepatic ischemia reperfusion injury

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dc.contributor.authorArslan, Mustafa
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorOzturk, Levent
dc.contributor.authorYaylak, Faik
dc.date.accessioned2020-06-25T18:06:49Z
dc.date.available2020-06-25T18:06:49Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063;
dc.description.abstractBackground: Hepatic ischemia-reperfusion injury is a common clinical problem in hepatic surgery and transplantation. Several cellular and tissue structural and functional alterations are observed in such injury. The aim of this study was to evaluate the effect of dexmedetomidine on lipid peroxidation and erythrocyte deformability during ischemia-reperfusion injury in rats. Methods: Twenty-four Wistar Albino rats were randomly separated into three groups as control (C), ischemia-reperfusion injury (I/R) and dexmedetomidine group (I/R-D). Ischemia was induced with portal clampage for 45 min and reperfusion period was 45 min after declampage. Group I/R-D received dexmedetomidine 100 mu g/kg i.p. 30 min before portal clampage. Serum malondialdehyde and superoxide dismutase activities to document lipid peroxidation and erythrocyte deformability index were investigated. Results: Serum superoxide dismutase and malondialdehyde activity levels were significantly higher and erythrocyte deformability index was decreased in hepatic ischemia-reperfusion group. However, these changes were observed to be prevented with dexmedetomidine treatment when given before portal clampage. Conclusion: These findings clearly indicate that erythrocyte deformability index is decreased in hepatic ischemia reperfusion injury and has a potential role to prevent these alterations. The protective effect of dexmedetomidine on hepatic I/R injury is also decreased lipid peroxidation. Further experimental and clinical investigations may clarify the molecular mechanisms and clinical significance of these findings.en_US
dc.identifier.citationArslan, M., Metin Çomu, F., Küçük, A., Oztürk, L., & Yaylak, F. (2012). Dexmedetomidine protects against lipid peroxidation and erythrocyte deformability alterations in experimental hepatic ischemia reperfusion injury. The Libyan journal of medicine, 7, 10.3402/ljm.v7i0.18185.en_US
dc.identifier.doi10.3402/ljm.v7i0.18185
dc.identifier.issn1993-2820
dc.identifier.issn1819-6357
dc.identifier.pmid22645631
dc.identifier.scopus2-s2.0-84864389201
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3402/ljm.v7i0.18185
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5366
dc.identifier.volume7en_US
dc.identifier.wosWOS:000305456200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofLibyan Journal Of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthepatic ischemia-reperfusion injuryen_US
dc.subjectlipid peroxidationen_US
dc.subjectmalondialdehydeen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectdexmedetomidineen_US
dc.titleDexmedetomidine protects against lipid peroxidation and erythrocyte deformability alterations in experimental hepatic ischemia reperfusion injuryen_US
dc.typeArticle

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