Protective effect of selenium on intussusception-induced ischemia/reperfusion intestinal oxidative injury in rats

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dc.contributor.authorAkman, Hulya
dc.contributor.authorSomuncu, Salih
dc.contributor.authorDikmen, Gunnur
dc.contributor.authorAyva, Sebnem
dc.contributor.authorSoyer, Tutku
dc.contributor.authorDogan, Pakize
dc.contributor.authorCakmak, Murat
dc.date.accessioned2020-06-25T17:51:14Z
dc.date.available2020-06-25T17:51:14Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionSoyer, Tutku/0000-0003-1505-6042
dc.description.abstractAim: To evaluate the protective effect of selenium on intestinal ischemia-reperfusion injury due to intussusception. Materials and methods: Forty Wistar albino rats were allocated to 4 equal groups (n = 10) After anesthetization, 2 cm of intestinal segment, 20 cm proximal to the ileocecal valve, was removed in the control group (CG) In the intussusception group (ING), intussusception was performed 20 cm proximal to the ileocecal valve by pushing the proximal intestinal segment distally with a stylet, and 2 cm of intestinal segment was removed 4 h later Intussusception was reduced and a 2 cm segment was removed after another 4 h period in the intussusception-reduction group (IRG). The selenium group (SG) received 0.2 mg kg(-1) of selenium in 10 mL of 0 9% NaCl solution intraperitoneally 20 min before reduction and segments were removed 411 thereafter Intestinal tissues were evaluated for histopathological grades and oxidative injury markers Results: Histopathologic evaluations among the 4 groups did not reveal a significant difference (P > 0 05) Although catalase activity was decreased in all groups, increased activity was found in SG compared with IRG (P < 0 05) GSH-Px and SOD activities were also found to have decreased in ING and IRG (P < 0 05) CG and SG had no difference in GSH-Px and SOD activities (P > 0 05) Malondialdehyde (MDA) activities did not differ between CG and SG, but the MDA level was Increased in ING and IRG when compared with CG (P < 0 05) Conclusion: Although selenium prevents oxidative injury by increasing the antioxidant enzyme activity in experimental intussusception, minim effects on histopathologic findings were not detecteden_US
dc.identifier.citationAkman, H., Somuncu, S., Dikmen, Z. G., Ayva, Ş., Soyer, T., Doğan, P., Çakmak, A. M. (2010). Protective effect of selenium on intussusception-induced ischemia/reperfusion intestinal oxidative injury in rats. Turkish Journal of Medical Sciences, 40(3), 391 - 397.en_US
dc.identifier.doi10.3906/sag-0904-25
dc.identifier.endpage397en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-77954416368
dc.identifier.scopusqualityQ1
dc.identifier.startpage391en_US
dc.identifier.trdizinid106450
dc.identifier.urihttps://doi.org/10.3906/sag-0904-25
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4742
dc.identifier.volume40en_US
dc.identifier.wosWOS:000280566800009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntussusceptionen_US
dc.subjectseleniumen_US
dc.subjectintestineen_US
dc.subjectischemia-reperfusionen_US
dc.subjectinjuryen_US
dc.subjectraten_US
dc.subjectoxidative stressen_US
dc.titleProtective effect of selenium on intussusception-induced ischemia/reperfusion intestinal oxidative injury in ratsen_US
dc.typeArticle

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