The role of oxidative damage in cataract etiopathogenesis

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dc.authoridATALAY, ENES/0000-0002-2718-9080
dc.authoridOgurel, Tevfik/0000-0003-0658-2286
dc.contributor.authorAtalay, Enes
dc.contributor.authorOgurel, Tevfik
dc.contributor.authorDerici, Mehmet Kursat
dc.date.accessioned2025-01-21T16:55:18Z
dc.date.available2025-01-21T16:55:18Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground:Cataract usually occurs due to age and diabetes, but the mechanisms of cataract formation have not yet been fully elucidated. In this study, the relationship between cataract and oxidative stress was evaluated by examining the aqueous humor reflecting lens metabolism. Objective:In this study, the effect of oxidative stress on the etiopathogenesis of cataract was investigated through the total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and arylesterase (ARE) levels in aqueous humor samples of patients with cataract. Design:A prospective cohort study. Methods:This study was conducted on patients who were scheduled for cataract surgery between June 2020 and March 2021. The patients were divided into four groups according to their cataract density as grades 1, 2, 3, and 4. TOS, TAS, and ARE levels of aqueous humor samples were measured spectrophotometrically, and comparisons were made between groups. Results:A total of 100 eyes of 100 patients were included in this study. TAS levels were found significantly higher in the grade 2 group compared with the grade 4 group (p = 0.006). In addition, a significant negative correlation was present between cataract grade and TAS level (r = -0.237; p = 0.018). There was no significant difference between diabetic and nondiabetic patients in terms of TAS, TOS, OSI, and ARE levels. Conclusion:The aqueous humor of patients with a high degree of cataract is characterized by low antioxidant capacity. Decreased antioxidant capacity has a role in cataract formation and progression.
dc.identifier.doi10.1177/25158414231168813
dc.identifier.issn2515-8414
dc.identifier.pmid37153694
dc.identifier.scopus2-s2.0-85160431746
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1177/25158414231168813
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25755
dc.identifier.volume15
dc.identifier.wosWOS:000979918400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofTherapeutic Advances In Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectaqueous humor; arylesterase; cataract; diabetes mellitus; oxidative stress
dc.titleThe role of oxidative damage in cataract etiopathogenesis
dc.typeArticle

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