Plasma lipocalin-2 levels in pregnancy

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dc.contributor.authorCesur, Semra
dc.contributor.authorYucel, Aykan
dc.contributor.authorNoyan, Volkan
dc.contributor.authorSagsoz, Nevin
dc.date.accessioned2020-06-25T18:06:53Z
dc.date.available2020-06-25T18:06:53Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionYucel, Aykan/0000-0002-5888-692X
dc.description.abstractObjective. To evaluate plasma levels of lipocalin-2, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Design. Prospective casecontrol study. Setting. University hospital. Population. Pregnant women with pre-pregnancy body mass index >25kg/m2 (overweight; n=29) and body mass index <25kg/m2 (n=27), whose gestational ages were between 24 and 28weeks, as study groups and nonpregnant control women with body mass index <25kg/m2 (n=29). Methods. Plasma lipocalin-2 levels, fasting plasma glucose and fasting plasma insulin levels; homeostasis model assessment insulin resistance index and fasting plasma glucose/fasting plasma insulin ratio were measured for each subject. Main Outcome Measures. Comparisons among the groups and correlations for lipocalin-2 and the parameters of insulin resistance. Results. Plasma lipocalin-2 levels among the pregnant women were significantly higher than those of the control group (p<0.001 for both group comparisons). Lipocalin-2 levels were significantly higher in the group with pre-pregnancy body mass index >25kg/m2 compared with the group with pre-pregnancy body mass index <25kg/m2 (p=0.003). Lipocalin-2 levels were positively correlated with homeostasis model assessment insulin resistance index and fasting plasma insulin and negatively correlated with fasting plasma glucose/fasting plasma insulin ratio in both pregnant groups. Conclusions. Lipocalin-2 was found to be higher in pregnant women, especially when pre-pregnancy body mass index was >25kg/m2, and it was correlated with markers of insulin resistance.en_US
dc.identifier.citationCesur, S., Yucel, A., Noyan, V., & Sagsoz, N. (2012). Plasma lipocalin-2 levels in pregnancy. Acta obstetricia et gynecologica Scandinavica, 91(1), 112–116.en_US
dc.identifier.doi10.1111/j.1600-0412.2011.01158.x
dc.identifier.endpage116en_US
dc.identifier.issn0001-6349
dc.identifier.issue1en_US
dc.identifier.pmid21504415
dc.identifier.scopus2-s2.0-83455225427
dc.identifier.scopusqualityQ1
dc.identifier.startpage112en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-0412.2011.01158.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5391
dc.identifier.volume91en_US
dc.identifier.wosWOS:000297922200018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofActa Obstetricia Et Gynecologica Scandinavica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLipocalin-2en_US
dc.subjectinsulin resistanceen_US
dc.subjectpregnancyen_US
dc.subjectoverweighten_US
dc.titlePlasma lipocalin-2 levels in pregnancyen_US
dc.typeArticle

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