Boron nitride decorated poly(vinyl alcohol)/poly(acrylic acid) composite nanofibers: A promising material for biomedical applications

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dc.authoridMetin, Ayşegül Ülkü/0000-0001-8494-601X
dc.authoridKaraduman, Fatma Rabia/0000-0001-7317-3445
dc.contributor.authorDogan, Deniz
dc.contributor.authorKaraduman, F. Rabia
dc.contributor.authorHorzum, Nesrin
dc.contributor.authorMetin, Ayşegül Ülkü
dc.date.accessioned2025-01-21T16:36:14Z
dc.date.available2025-01-21T16:36:14Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, polyvinyl alcohol (PVA) and polyacrylic acid (PAA) nanofibers loaded with boron nitride nano-particles (mBN) were fabricated by using electrospinning and crosslinked by heat treatment. The physical, chemical, and mechanical properties, hydrophilic behavior, and degradability of composite nanofibers were evaluated. The mechanical properties such as elastic modulus, elongation percentage at the break, and mechanical strength of PVA/PAA nanofibers improved with mBN loading. The thermal conductivity of composite nanofibers reached 0.12 W/m center dot K at mBN content of 1.0 wt% due to the continuous heat conduction pathways of mBN. In the meantime, while there was no cytotoxicity recorded for both L929 and HUVEC cell lines for all composite nanofibers, the antimicrobial efficiency improved with the incorporation of mBN compared with PVA/PAA and recorded as 68.8% and 75.1% for Escherichia coli and Staphylococcus aureus, respectively. On this basis, the present work proposes a promising biomaterial for biomedical applications such as dual drug delivery, particularly including both hydrophobic and hydrophilic drugs or wound dressing.
dc.identifier.doi10.1016/j.jmbbm.2023.105773
dc.identifier.issn1751-6161
dc.identifier.issn1878-0180
dc.identifier.pmid36934687
dc.identifier.scopus2-s2.0-85150411910
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jmbbm.2023.105773
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24283
dc.identifier.volume141
dc.identifier.wosWOS:000957280300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of The Mechanical Behavior of Biomedical Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectElectrospun fiber; Boron nitride; Mechanical; Thermal and biological properties
dc.titleBoron nitride decorated poly(vinyl alcohol)/poly(acrylic acid) composite nanofibers: A promising material for biomedical applications
dc.typeArticle

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