Effects of bisphenol A, diethylhexyl phthalate and pentabrominated diphenyl ether 99 on steroid synthesis in cultured bovine luteal cells

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dc.contributor.authorKabakci, Ruhi
dc.contributor.authorYigit, A. Arzu
dc.date.accessioned2021-01-14T18:10:47Z
dc.date.available2021-01-14T18:10:47Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionKABAKCI, Ruhi/0000-0001-9131-0933; YIgit, Ayse Arzu/0000-0001-5837-6877
dc.description.abstractBisphenol A (BPA), diethylhexyl phthalate (DEHP) and pentabrominated diphenyl ether 99 (PBDE 99) are environmental toxicants belonging to the endocrine disrupting compounds (EDCs). They exert adverse effects on the various physiological systems, especially the reproductive system of humans and animals. The aim of this study was to investigate the effects of BPA, DEHP and PBDE 99 on progesterone (P4) synthesis in cultured bovine luteal cells. The bovine luteal cells isolated from the mid-luteal corpora lutea were exposed to different concentrations of BPA (1, 3, 10 and 30 mu M), DEHP (1, 3, 10 and 30 mu M) and PBDE 99 (0.1, 0.3, 1 and 3 mu M) in a serum-free culture media for 48 and 96 hr. At 48 hr, the P4 level in the luteal cells decreased after treatment with all concentrations of BPA; 3, 10 and 30 mu M of DEHP; and 3 mu M of PBDE 99 compared to the control (p < .05). Treatment of cells with 3-30 mu M of BPA, 1-30 mu M of DEHP and 1-3 mu M of PBDE 99 for 96 hr resulted in reduction in P4 synthesis (p < .05). However, lower concentrations of PBDE 99 (0.1 and 0.3 mu M) increased P4 levels at 48 and 96 hr. Synthesis of P4 was lower at 96 hr compared to the 48 hr in the groups treated with BPA (30 mu M), DEHP (1-30 mu M), PBDE 99 (0.3-3 mu M) and control group. Our results showed that BPA, DEHP and PBDE 99 are able to alter luteal steroidogenesis in bovine cells and can disrupt hormonal balance in the ovary. However, it is necessary to evaluate the exact mechanism underlying these effects in future studies.en_US
dc.description.sponsorshipKirikkale University, Scientific Research Projects Coordination UnitKirikkale University [2015/129]en_US
dc.description.sponsorshipKirikkale University, Scientific Research Projects Coordination Unit, Grant/Award Number: 2015/129en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1111/rda.13665
dc.identifier.endpage690en_US
dc.identifier.issn0936-6768
dc.identifier.issn1439-0531
dc.identifier.issue6en_US
dc.identifier.pmid32125030
dc.identifier.scopus2-s2.0-85082054273
dc.identifier.scopusqualityQ2
dc.identifier.startpage683en_US
dc.identifier.urihttps://doi.org/10.1111/rda.13665
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12769
dc.identifier.volume55en_US
dc.identifier.wosWOS:000520762900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWILEYen_US
dc.relation.ispartofREPRODUCTION IN DOMESTIC ANIMALS
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbovineen_US
dc.subjectBPAen_US
dc.subjectDEHPen_US
dc.subjectEDCsen_US
dc.subjectluteal cellsen_US
dc.subjectPBDE 99en_US
dc.subjectreproductive systemen_US
dc.titleEffects of bisphenol A, diethylhexyl phthalate and pentabrominated diphenyl ether 99 on steroid synthesis in cultured bovine luteal cellsen_US
dc.typeArticle

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