Bioactivity of Centaurea persica boiss. (Asteraceae)

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dc.contributor.authorSarker, Satyajit D.
dc.contributor.authorNahar, Lutfun
dc.contributor.authorGujja, Srikanth
dc.contributor.authorBegum, Shazi
dc.contributor.authorCelik, Sezgin
dc.date.accessioned2020-06-25T18:06:49Z
dc.date.available2020-06-25T18:06:49Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe free-radical-scavenging property, antibacterial activity and brine shrimp toxicity of petroleum ether (PE), dichloromethane (DCM) and methanol (MeOH) extracts of Centaurea persica, a Turkish medicinal plant, were assessed using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the resazurin microtiter plate based assay, and the brine shrimp lethality assay, respectively. Additionally, the disc diffusion assay was also used to assess antibacterial activity. Only the MeOH extract of C. persica exhibited a significant free-radical-scavenging property in the DPPH assay, with an RC50 value of 0.025 mg/mL. However, in the TLC-based qualitative assay, petroleum ether and DCM extracts showed an extremely low level of free-radical-scavenging property. Among the solid-phase extraction fractions of the MeOH extract, the fractions eluted with 60% and 80% MeOH in water exhibited the highest level of free-radical-scavenging activity (RC50 = 0.010 and 0.015 mg/mL, respectively). While DCM extract showed reasonable antibacterial activity against five out of the nine test strains both in the disc diffusion assay and in the resazurin assay, the MeOH extract was highly active against both Escherichia coli and ampicillin-resistant E. coli strains. Among the solid-phase extraction fractions of the MeOH extract, fractions eluted with 80% MeOH in water and 100% MeOH displayed significant antibacterial potencies against both E. coli species. None of the extracts showed any significant toxicity towards brine shrimps (LD50 = >1.00 mg/mL).en_US
dc.identifier.citationSarker, Satyajit & Nahar, Dr Lutfun & Gujja, Srikanth & Begum, Shazi & Celik, Sezgin. (2012). Bioactivity of Centaurea persica Boiss. (Asteraceae). Archives of Biological Sciences. 64(2), 517-523.en_US
dc.identifier.doi10.2298/ABS1202517S
dc.identifier.endpage523en_US
dc.identifier.issn0354-4664
dc.identifier.issn1821-4339
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84862256403
dc.identifier.scopusqualityQ3
dc.identifier.startpage517en_US
dc.identifier.urihttps://doi.org/10.2298/ABS1202517S
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5369
dc.identifier.volume64en_US
dc.identifier.wosWOS:000304339100016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInst Bioloska Istrazivanja Sinisa Stankovicen_US
dc.relation.ispartofArchives Of Biological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCentaurea persicaen_US
dc.subjectAsteraceaeen_US
dc.subjectfree-radical-scavenging activityen_US
dc.subjectantioxidant activityen_US
dc.subjectantibacterial activityen_US
dc.subjectresazurin assayen_US
dc.subjectDPPHen_US
dc.subjectbrine shrimp lethality assayen_US
dc.titleBioactivity of Centaurea persica boiss. (Asteraceae)en_US
dc.typeArticle

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